@article{18fd74b074c311dbbee902004c4f4f50,
title = "Localization of checkpoint and repair proteins in eukaryotes",
abstract = "In eukaryotes, the cellular response to DNA damage depends on the type of DNA structure being recognized by the checkpoint and repair machinery. DNA ends and single-stranded DNA are hallmarks of double-strand breaks and replication stress. These two structures are recognized by distinct sets of proteins, which are reorganized into a focal assembly at the lesion. Moreover, the composition of these foci is coordinated with cell cycle progression, reflecting the favoring of end-joining in the G1 phase and homologous recombination in S and G2. The assembly of proteins at sites of DNA damage is largely controlled by a network of protein-protein interactions, with the Mre11 complex initiating assembly at DNA ends and replication protein A directing recruitment to single-stranded DNA. This review summarizes current knowledge on the cellular organization of DSB repair and checkpoint proteins focusing on budding yeast and mammalian cells.",
author = "Michael Lisby and Rodney Rothstein",
note = "Keywords: Double-strand break; Replication; DNA damage; Checkpoint; Foci; Homologous recombination; Non-homologous end-joining; Repair center",
year = "2005",
doi = "10.1016/j.biochi.2004.10.023",
language = "English",
volume = "87",
pages = "579--589",
journal = "Biochimie",
issn = "0300-9084",
publisher = "Elsevier Masson",
number = "7",
}