The intention with this volume is to provide a format for scholars to express their personal viewpoints and tell their story in response to the same set of questions (see Preface). Unlike many edited volumes, this book is therefore not divided into thematic sections. The aim of this introduction is to summarize core common themes among the contributor’s chapters so as to guide readers interested in specific topics. Given the richness of the contributions that touch upon many diverse topics in response to the posed questions, I have not summarized each contribution separately. Rather, I focus on core questions and highlight where more information on common themes and novel insights can be found. I also hope that the introduction will provide some background for scientists, philosophers, as well as other readers interested in discussing the philosophical implications of systems biology.