Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

U Frandsen; J Bangsbo; Henning Langberg; B Saltin; Y Hellsten

doi:25743

Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

U Frandsen, J Bangsbo, Henning Langberg, B Saltin, Y Hellsten

44 Citationer (Scopus)

Abstract

We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p

Originalsprog	Engelsk
Tidsskrift	Journal of Vascular Research
Vol/bind	37
Udgave nummer	4
Sider (fra-til)	297-302
Antal sider	6
ISSN	1018-1172
DOI	https://doi.org/25743
Status	Udgivet - 2000

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Citationsformater

Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans : effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. / Frandsen, U; Bangsbo, J ; Langberg, Henning et al.

I: Journal of Vascular Research, Bind 37, Nr. 4, 2000, s. 297-302.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Frandsen, U, Bangsbo, J , Langberg, H, Saltin, B & Hellsten, Y 2000, 'Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle', Journal of Vascular Research, bind 37, nr. 4, s. 297-302. https://doi.org/25743

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title = "Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle",

abstract = "We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p",

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author = "U Frandsen and J Bangsbo and Henning Langberg and B Saltin and Y Hellsten",

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T1 - Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans

T2 - effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

AU - Frandsen, U

AU - Bangsbo, J

AU - Langberg, Henning

AU - Saltin, B

AU - Hellsten, Y

PY - 2000

Y1 - 2000

N2 - We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p

AB - We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p

KW - 6-Ketoprostaglandin F1 alpha

KW - Adenosine

KW - Adult

KW - Blood Pressure

KW - Enzyme Inhibitors

KW - Epoprostenol

KW - Extracellular Space

KW - Humans

KW - Leg

KW - Male

KW - Muscle Contraction

KW - Muscle, Skeletal

KW - Nitric Oxide

KW - Osmolar Concentration

KW - Potassium

KW - Regional Blood Flow

KW - Rest

KW - omega-N-Methylarginine

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DO - 25743

M3 - Journal article

C2 - 10965228

SN - 1018-1172

VL - 37

SP - 297

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JO - Journal of Vascular Research

JF - Journal of Vascular Research

IS - 4

ER -