Iminolactones from Schizophyllum commune

Xuemei Liu; Karla Andrea Frydenvang; Huizhen Liu; Lin Zhai; Ming Chen; Carl Erik Olsen; Søren Brøgger Christensen

doi:10.1021/np500836y

Iminolactones from Schizophyllum commune

Xuemei Liu, Karla Andrea Frydenvang, Huizhen Liu, Lin Zhai, Ming Chen, Carl Erik Olsen, Søren Brøgger Christensen

Plantebiokemi

10 Citationer (Scopus)

Abstract

Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.

Originalsprog	Engelsk
Tidsskrift	Journal of Natural Products
Vol/bind	78
Udgave nummer	5
Sider (fra-til)	1165-1168
Antal sider	4
ISSN	0974-5211
DOI	https://doi.org/10.1021/np500836y
Status	Udgivet - 22 maj 2015

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10.1021/np500836y

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title = "Iminolactones from Schizophyllum commune",

abstract = "Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.",

keywords = "Faculty of Health and Medical Sciences, Natural products, Iminolactones, Schizophyllum commune",

author = "Xuemei Liu and Frydenvang, {Karla Andrea} and Huizhen Liu and Lin Zhai and Ming Chen and Olsen, {Carl Erik} and Christensen, {S{\o}ren Br{\o}gger}",

year = "2015",

month = may,

day = "22",

doi = "10.1021/np500836y",

language = "English",

volume = "78",

pages = "1165--1168",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Iminolactones from Schizophyllum commune

AU - Liu, Xuemei

AU - Frydenvang, Karla Andrea

AU - Liu, Huizhen

AU - Zhai, Lin

AU - Chen, Ming

AU - Olsen, Carl Erik

AU - Christensen, Søren Brøgger

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.

AB - Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.

KW - Faculty of Health and Medical Sciences

KW - Natural products

KW - Iminolactones

KW - Schizophyllum commune

U2 - 10.1021/np500836y

DO - 10.1021/np500836y

M3 - Journal article

C2 - 25951057

SN - 0974-5211

VL - 78

SP - 1165

EP - 1168

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Iminolactones from Schizophyllum commune

Abstract

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