Faecalibacterium gut colonization is accelerated by presence of older siblings

TY - JOUR

T1 - Faecalibacterium gut colonization is accelerated by presence of older siblings

AU - Laursen, Martin Frederik

AU - Laursen, Rikke Pilmann

AU - Larnkjær, Anni

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

AU - Frøkiær, Hanne

AU - Bahl, Martin Iain

AU - Licht, Tine Rask

N1 - CURIS 2017 NEXS 339

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings.

AB - Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings.

KW - Faecalibacterium

KW - Infancy

KW - Siblings

U2 - 10.1128/mSphere.00448-17

DO - 10.1128/mSphere.00448-17

M3 - Journal article

C2 - 29202044

SN - 2379-5042

VL - 2

JO - mSphere

JF - mSphere

IS - 6

M1 - e00448-17

ER -