Faecalibacterium gut colonization is accelerated by presence of older siblings

Martin Frederik Laursen; Rikke Pilmann Laursen; Anni Larnkjær; Christian Mølgaard; Kim F. Michaelsen; Hanne Frøkiær; Martin Iain Bahl; Tine Rask Licht

doi:10.1128/mSphere.00448-17

Faecalibacterium gut colonization is accelerated by presence of older siblings

Martin Frederik Laursen, Rikke Pilmann Laursen, Anni Larnkjær, Christian Mølgaard, Kim F. Michaelsen, Hanne Frøkiær, Martin Iain Bahl, Tine Rask Licht

Lifecourse Nutrition & Health

13 Citations (Scopus)

46 Downloads (Pure)

Abstract

Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings.

Original language	English
Article number	e00448-17
Journal	mSphere
Volume	2
Issue number	6
Number of pages	6
ISSN	2379-5042
DOIs	https://doi.org/10.1128/mSphere.00448-17
Publication status	Published - 1 Nov 2017

Keywords

Faecalibacterium
Infancy
Siblings

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/mSphere.00448-17Licence: CC BY

Faecalibacterium Gut Colonization Is Accelerated by Presence of Older SiblingsFinal published version, 278 KBLicence: CC BY

Cite this

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title = "Faecalibacterium gut colonization is accelerated by presence of older siblings",

abstract = "Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings.",

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author = "Laursen, {Martin Frederik} and Laursen, {Rikke Pilmann} and Anni Larnkj{\ae}r and Christian M{\o}lgaard and Michaelsen, {Kim F.} and Hanne Fr{\o}ki{\ae}r and Bahl, {Martin Iain} and Licht, {Tine Rask}",

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T1 - Faecalibacterium gut colonization is accelerated by presence of older siblings

AU - Laursen, Martin Frederik

AU - Laursen, Rikke Pilmann

AU - Larnkjær, Anni

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

AU - Frøkiær, Hanne

AU - Bahl, Martin Iain

AU - Licht, Tine Rask

N1 - CURIS 2017 NEXS 339

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings.

AB - Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings.

KW - Faecalibacterium

KW - Infancy

KW - Siblings

U2 - 10.1128/mSphere.00448-17

DO - 10.1128/mSphere.00448-17

M3 - Journal article

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SN - 2379-5042

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