Functional Modeling of Neural-Glia Interaction

TY - CHAP

T1 - Functional Modeling of Neural-Glia Interaction

AU - Postnov, D.E.

AU - Brazhe, N.A.

AU - Sosnovtseva, Olga

PY - 2012/1/1

Y1 - 2012/1/1

N2 - During recent years the importance of neuro-glial interactions for the maintenance of the normal function of the central and peripheral nervous systems has been fully recognized [10, 8]. The restricted perspective on the role of the glial cells to provide only metabolic support and uptake of K+ions and neurotransmitters no longer agrees with data that reveal their participation in synaptic transmission, long-term potentiation, synaptic plasticity, and the development of neuronal pathologies. As a result the new concept of the tripartite synapse has emerged [23], and studies of the interaction between the neurons and glial cells have become an important area of neurophysiology and cell biophysics.

AB - During recent years the importance of neuro-glial interactions for the maintenance of the normal function of the central and peripheral nervous systems has been fully recognized [10, 8]. The restricted perspective on the role of the glial cells to provide only metabolic support and uptake of K+ions and neurotransmitters no longer agrees with data that reveal their participation in synaptic transmission, long-term potentiation, synaptic plasticity, and the development of neuronal pathologies. As a result the new concept of the tripartite synapse has emerged [23], and studies of the interaction between the neurons and glial cells have become an important area of neurophysiology and cell biophysics.

U2 - 10.1007/978-3-7091-0418-7_6

DO - 10.1007/978-3-7091-0418-7_6

M3 - Book chapter

SN - 978-3-7091-0417-0

SP - 133

EP - 151

BT - Biosimulation in Biomedical Research, Health Care and Drug Development

A2 - Mosekilde, Erik

A2 - Sosnovtseva, Olga

A2 - Rostami-Hodjegan, Amin

PB - Springer

ER -