Keyphrases
Enthalpy-entropy Compensation
100%
Ionotropic Receptor
100%
Glutamate Receptors
100%
Hydroxyl Group
100%
Benzothiadiazine 1,1-dioxide
25%
Alzheimer's Disease
25%
Binding Entropy
25%
Positive Allosteric Modulator
25%
Binding Mode
25%
Conformational Restriction
25%
Desolvation Effect
25%
X-ray Crystallography
25%
IC50 Value
25%
Drug Development
25%
Ligand-binding Domain
25%
Hydrogen Bonds (H-bonds)
25%
Structural Mechanism
25%
Cognitive Disorders
25%
Fluorine Substitution
25%
Side Chain
25%
L-glutamine
25%
Dissociation Constant
25%
Open Channel
25%
Homomeric
25%
Biochemistry, Genetics and Molecular Biology
Glutamate Receptor
100%
Ionotropic Glutamate Receptor
100%
Enthalpy
100%
Ionotropic Receptor
100%
Hydrogen Bond
25%
Conformation
25%
Dissociation Constant
25%
Agonist
25%
EC50
25%
Ligand Binding Domain
25%
Glutamic Acid
25%
Benzothiadiazine
25%
Chemistry
Enthalpy
100%
Glutamic Acid
100%
Hydroxyl Group
80%
Ligand Binding Domain
20%
Desolvation
20%
Fluorine
20%
formation
20%
EC50
20%
Kd
20%
Lead Compound
20%
Benzothiadiazine
20%
Hydrogen Bonding
20%