Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study

Lillian Jespersen; Inge Tarnow; Dorte Eskesen; Cathrine Melsaether Morberg; Birgit Michelsen; Susanne Gjedsted Bügel; Lars Ove Dragsted; Ger T Rijkers; Philip C Calder

doi:10.3945/ajcn.114.103531

Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study

Lillian Jespersen, Inge Tarnow, Dorte Eskesen, Cathrine Melsaether Morberg, Birgit Michelsen, Susanne Gjedsted Bügel, Lars Ove Dragsted, Ger T Rijkers, Philip C Calder

Ernæring og Sundhed

37 Citationer (Scopus)

Abstract

Background: Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections. Objective: The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L.casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults. Design: A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥10⁹ colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded. Results: There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity. Conclusions: Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.

Originalsprog	Engelsk
Tidsskrift	American Journal of Clinical Nutrition
Vol/bind	101
Udgave nummer	6
Sider (fra-til)	1188-1196
Antal sider	9
ISSN	0002-9165
DOI	https://doi.org/10.3945/ajcn.114.103531
Status	Udgivet - 1 jun. 2015

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Citationsformater

Jespersen, L., Tarnow, I., Eskesen, D., Morberg, C. M., Michelsen, B., Bügel, S. G., Dragsted, L. O., Rijkers, G. T., & Calder, P. C. (2015). Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. American Journal of Clinical Nutrition, 101(6), 1188-1196. https://doi.org/10.3945/ajcn.114.103531

Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. / Jespersen, Lillian; Tarnow, Inge; Eskesen, Dorte et al.
I: American Journal of Clinical Nutrition, Bind 101, Nr. 6, 01.06.2015, s. 1188-1196.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jespersen, L, Tarnow, I, Eskesen, D, Morberg, CM, Michelsen, B, Bügel, SG , Dragsted, LO, Rijkers, GT & Calder, PC 2015, 'Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study', American Journal of Clinical Nutrition, bind 101, nr. 6, s. 1188-1196. https://doi.org/10.3945/ajcn.114.103531

Jespersen L, Tarnow I, Eskesen D, Morberg CM, Michelsen B, Bügel SG et al. Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. American Journal of Clinical Nutrition. 2015 jun. 1;101(6):1188-1196. doi: 10.3945/ajcn.114.103531

Jespersen, Lillian ; Tarnow, Inge ; Eskesen, Dorte et al. / Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers : a randomized, double-blind, placebo-controlled, parallel-group study. I: American Journal of Clinical Nutrition. 2015 ; Bind 101, Nr. 6. s. 1188-1196.

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abstract = "Background: Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections. Objective: The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L.casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults. Design: A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥109 colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded. Results: There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity. Conclusions: Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.",

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T1 - Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers

T2 - a randomized, double-blind, placebo-controlled, parallel-group study

AU - Jespersen, Lillian

AU - Tarnow, Inge

AU - Eskesen, Dorte

AU - Morberg, Cathrine Melsaether

AU - Michelsen, Birgit

AU - Bügel, Susanne Gjedsted

AU - Dragsted, Lars Ove

AU - Rijkers, Ger T

AU - Calder, Philip C

N1 - CURIS 2015 NEXS 182

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Y1 - 2015/6/1

N2 - Background: Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections. Objective: The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L.casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults. Design: A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥109 colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded. Results: There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity. Conclusions: Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.

AB - Background: Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections. Objective: The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L.casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults. Design: A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥109 colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded. Results: There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity. Conclusions: Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.

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DO - 10.3945/ajcn.114.103531

M3 - Journal article

C2 - 25926507

SN - 0002-9165

VL - 101

SP - 1188

EP - 1196

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 6

ER -