Abstract
OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.
METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.
RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.
CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Acta Neuropsychiatrica (Print) |
| Vol/bind | 27 |
| Udgave nummer | 5 |
| Sider (fra-til) | 307-311 |
| Antal sider | 5 |
| ISSN | 0924-2708 |
| DOI | |
| Status | Udgivet - 16 mar. 2015 |
Emneord
- Det Sundhedsvidenskabelige Fakultet
- animal models
- anxiety
- gut microbiota
- magnesium