TY - JOUR
T1 - Developments in hollow fibre-based, liquid-phase microextraction
AU - Rasmussen, Knut Einar
AU - Pedersen-Bjergaard, Stig
PY - 2004/1
Y1 - 2004/1
N2 - The demand for automation in analytical liquid-liquid extraction (LLE) combined with organic solvent reduction or elimination has led to the recent development of liquid-phase microextraction (LPME) based on disposable hollow fibres. In this concept, analytes of interest are extracted from aqueous samples, through a thin layer of organic solvent immobilized within the pores of a porous hollow fibre, and into an acceptor solution inside the lumen of the hollow fibre. Subsequently, the acceptor solution is directly subjected to a final analysis by capillary gas chromatography (CGC), high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), or mass spectrometry (MS) without any further effort. Hollow fibre-based LPME may provide high analyte pre-concentration and excellent sample clean-up, and it has a broad application potential within areas such as drug analysis and environmental monitoring. This review focuses on basic extraction principles, technical set-up, recovery, enrichment, extraction speed, selectivity, applications, and future trends in hollow fibre-based LPME.
AB - The demand for automation in analytical liquid-liquid extraction (LLE) combined with organic solvent reduction or elimination has led to the recent development of liquid-phase microextraction (LPME) based on disposable hollow fibres. In this concept, analytes of interest are extracted from aqueous samples, through a thin layer of organic solvent immobilized within the pores of a porous hollow fibre, and into an acceptor solution inside the lumen of the hollow fibre. Subsequently, the acceptor solution is directly subjected to a final analysis by capillary gas chromatography (CGC), high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), or mass spectrometry (MS) without any further effort. Hollow fibre-based LPME may provide high analyte pre-concentration and excellent sample clean-up, and it has a broad application potential within areas such as drug analysis and environmental monitoring. This review focuses on basic extraction principles, technical set-up, recovery, enrichment, extraction speed, selectivity, applications, and future trends in hollow fibre-based LPME.
KW - Drug analysis
KW - Environmental analysis
KW - Extraction techniques
KW - Hollow fibres
KW - Liquid-phase microextraction
UR - http://www.scopus.com/inward/record.url?scp=0346687607&partnerID=8YFLogxK
U2 - 10.1016/S0165-9936(04)00105-0
DO - 10.1016/S0165-9936(04)00105-0
M3 - Journal article
AN - SCOPUS:0346687607
SN - 0165-9936
VL - 23
SP - 1
EP - 10
JO - Trends in Analytical Chemistry
JF - Trends in Analytical Chemistry
IS - 1
ER -