Abstract
The demand for automation in analytical liquid-liquid extraction (LLE) combined with organic solvent reduction or elimination has led to the recent development of liquid-phase microextraction (LPME) based on disposable hollow fibres. In this concept, analytes of interest are extracted from aqueous samples, through a thin layer of organic solvent immobilized within the pores of a porous hollow fibre, and into an acceptor solution inside the lumen of the hollow fibre. Subsequently, the acceptor solution is directly subjected to a final analysis by capillary gas chromatography (CGC), high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), or mass spectrometry (MS) without any further effort. Hollow fibre-based LPME may provide high analyte pre-concentration and excellent sample clean-up, and it has a broad application potential within areas such as drug analysis and environmental monitoring. This review focuses on basic extraction principles, technical set-up, recovery, enrichment, extraction speed, selectivity, applications, and future trends in hollow fibre-based LPME.
| Original language | English |
|---|---|
| Journal | TrAC - Trends in Analytical Chemistry |
| Volume | 23 |
| Issue number | 1 |
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| ISSN | 0165-9936 |
| DOIs | |
| Publication status | Published - Jan 2004 |
Keywords
- Drug analysis
- Environmental analysis
- Extraction techniques
- Hollow fibres
- Liquid-phase microextraction