Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Henrik Munch Roager; Lea Benedicte Skov Hansen; Martin I Bahl; Henrik Lauritz Frandsen; Vera Carvalho; Rikke J Gøbel; Marlene Danner Dalgaard; Damian Rafal Plichta; Morten H Sparholt; Henrik Vestergaard; Torben Hansen; Thomas Sicheritz-Ponten; H Bjørn Nielsen; Oluf Pedersen; Lotte Lauritzen; Mette Bredal Kristensen; Ramneek Gupta; Tine R Licht

doi:10.1038/nmicrobiol.2016.93

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Henrik Munch Roager, Lea Benedicte Skov Hansen, Martin I Bahl, Henrik Lauritz Frandsen, Vera Carvalho, Rikke J Gøbel, Marlene Danner Dalgaard, Damian Rafal Plichta, Morten H Sparholt, Henrik Vestergaard, Torben Hansen, Thomas Sicheritz-Ponten, H Bjørn Nielsen, Oluf Pedersen, Lotte Lauritzen, Mette Bredal Kristensen, Ramneek Gupta, Tine R Licht

146 Citationer (Scopus)

Abstract

Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.

Originalsprog	Engelsk
Artikelnummer	16093
Tidsskrift	Nature Microbiology
Vol/bind	1
Udgave nummer	9
Antal sider	9
ISSN	2058-5276
DOI	https://doi.org/10.1038/nmicrobiol.2016.93
Status	Udgivet - 27 jun. 2016

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1038/nmicrobiol.2016.93

Citationsformater

Roager, H. M., Hansen, L. B. S., Bahl, M. I., Frandsen, H. L., Carvalho, V., Gøbel, R. J., Dalgaard, M. D., Plichta, D. R., Sparholt, M. H., Vestergaard, H., Hansen, T., Sicheritz-Ponten, T., Nielsen, H. B., Pedersen, O., Lauritzen, L., Kristensen, M. B., Gupta, R., & Licht, T. R. (2016). Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut. Nature Microbiology, 1(9), [16093]. https://doi.org/10.1038/nmicrobiol.2016.93

Roager, HM, Hansen, LBS, Bahl, MI, Frandsen, HL, Carvalho, V, Gøbel, RJ, Dalgaard, MD, Plichta, DR, Sparholt, MH, Vestergaard, H , Hansen, T, Sicheritz-Ponten, T, Nielsen, HB, Pedersen, O , Lauritzen, L, Kristensen, MB, Gupta, R & Licht, TR 2016, 'Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut', Nature Microbiology, bind 1, nr. 9, 16093. https://doi.org/10.1038/nmicrobiol.2016.93

@article{ce286bbee0e2453393e3103c96f7f31b,

title = "Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut",

abstract = "Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.",

keywords = "Journal Article",

author = "Roager, {Henrik Munch} and Hansen, {Lea Benedicte Skov} and Bahl, {Martin I} and Frandsen, {Henrik Lauritz} and Vera Carvalho and G{\o}bel, {Rikke J} and Dalgaard, {Marlene Danner} and Plichta, {Damian Rafal} and Sparholt, {Morten H} and Henrik Vestergaard and Torben Hansen and Thomas Sicheritz-Ponten and Nielsen, {H Bj{\o}rn} and Oluf Pedersen and Lotte Lauritzen and Kristensen, {Mette Bredal} and Ramneek Gupta and Licht, {Tine R}",

note = "CURIS 2016 NEXS 252",

year = "2016",

month = jun,

day = "27",

doi = "10.1038/nmicrobiol.2016.93",

language = "English",

volume = "1",

journal = "Nature Microbiology",

issn = "2058-5276",

publisher = "nature publishing group",

number = "9",

}

TY - JOUR

T1 - Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

AU - Roager, Henrik Munch

AU - Hansen, Lea Benedicte Skov

AU - Bahl, Martin I

AU - Frandsen, Henrik Lauritz

AU - Carvalho, Vera

AU - Gøbel, Rikke J

AU - Dalgaard, Marlene Danner

AU - Plichta, Damian Rafal

AU - Sparholt, Morten H

AU - Vestergaard, Henrik

AU - Hansen, Torben

AU - Sicheritz-Ponten, Thomas

AU - Nielsen, H Bjørn

AU - Pedersen, Oluf

AU - Lauritzen, Lotte

AU - Kristensen, Mette Bredal

AU - Gupta, Ramneek

AU - Licht, Tine R

N1 - CURIS 2016 NEXS 252

PY - 2016/6/27

Y1 - 2016/6/27

N2 - Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.

AB - Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.

KW - Journal Article

U2 - 10.1038/nmicrobiol.2016.93

DO - 10.1038/nmicrobiol.2016.93

M3 - Journal article

C2 - 27562254

SN - 2058-5276

VL - 1

JO - Nature Microbiology

JF - Nature Microbiology

IS - 9

M1 - 16093

ER -

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater