Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Henrik Munch Roager; Lea Benedicte Skov Hansen; Martin I Bahl; Henrik Lauritz Frandsen; Vera Carvalho; Rikke J Gøbel; Marlene Danner Dalgaard; Damian Rafal Plichta; Morten H Sparholt; Henrik Vestergaard; Torben Hansen; Thomas Sicheritz-Ponten; H Bjørn Nielsen; Oluf Pedersen; Lotte Lauritzen; Mette Bredal Kristensen; Ramneek Gupta; Tine R Licht

doi:10.1038/nmicrobiol.2016.93

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Henrik Munch Roager, Lea Benedicte Skov Hansen, Martin I Bahl, Henrik Lauritz Frandsen, Vera Carvalho, Rikke J Gøbel, Marlene Danner Dalgaard, Damian Rafal Plichta, Morten H Sparholt, Henrik Vestergaard, Torben Hansen, Thomas Sicheritz-Ponten, H Bjørn Nielsen, Oluf Pedersen, Lotte Lauritzen, Mette Bredal Kristensen, Ramneek Gupta, Tine R Licht

146 Citations (Scopus)

Abstract

Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.

Original language	English
Article number	16093
Journal	Nature Microbiology
Volume	1
Issue number	9
Number of pages	9
ISSN	2058-5276
DOIs	https://doi.org/10.1038/nmicrobiol.2016.93
Publication status	Published - 27 Jun 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nmicrobiol.2016.93

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Roager, H. M., Hansen, L. B. S., Bahl, M. I., Frandsen, H. L., Carvalho, V., Gøbel, R. J., Dalgaard, M. D., Plichta, D. R., Sparholt, M. H., Vestergaard, H., Hansen, T., Sicheritz-Ponten, T., Nielsen, H. B., Pedersen, O., Lauritzen, L., Kristensen, M. B., Gupta, R., & Licht, T. R. (2016). Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut. Nature Microbiology, 1(9), Article 16093. https://doi.org/10.1038/nmicrobiol.2016.93

Roager, HM, Hansen, LBS, Bahl, MI, Frandsen, HL, Carvalho, V, Gøbel, RJ, Dalgaard, MD, Plichta, DR, Sparholt, MH, Vestergaard, H , Hansen, T, Sicheritz-Ponten, T, Nielsen, HB, Pedersen, O , Lauritzen, L, Kristensen, MB, Gupta, R & Licht, TR 2016, 'Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut', Nature Microbiology, vol. 1, no. 9, 16093. https://doi.org/10.1038/nmicrobiol.2016.93

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abstract = "Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.",

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AB - Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.

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Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Abstract

Keywords

UN SDGs

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