TY - JOUR
T1 - Biomedical application and controlled drug release of electrospun fibrous materials
AU - Cheng, Huiling
AU - Yang, Xiaoye
AU - Che, Xin
AU - Yang, Mingshi
AU - Zhai, Guangxi
PY - 2018
Y1 - 2018
N2 - Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. This review focuses on the recent advances in biomedical application of EFM, controlled drug release from EFM and devices for producing sophisticated EFM. The processing parameters which influence the physicochemical properties of the resulting EFM are also summarized as well as scaling up techniques for mass production of EFM.
AB - Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. This review focuses on the recent advances in biomedical application of EFM, controlled drug release from EFM and devices for producing sophisticated EFM. The processing parameters which influence the physicochemical properties of the resulting EFM are also summarized as well as scaling up techniques for mass production of EFM.
KW - Biomedical application
KW - Controlled drug release
KW - Electrospinning
KW - Membranes
KW - Scaffolds
U2 - 10.1016/j.msec.2018.05.007
DO - 10.1016/j.msec.2018.05.007
M3 - Review
C2 - 29853146
AN - SCOPUS:85046632391
SN - 0921-5093
VL - 90
SP - 750
EP - 763
JO - Materials Science and Engineering: A
JF - Materials Science and Engineering: A
ER -