Biomedical application and controlled drug release of electrospun fibrous materials

TY - JOUR

T1 - Biomedical application and controlled drug release of electrospun fibrous materials

AU - Cheng, Huiling

AU - Yang, Xiaoye

AU - Che, Xin

AU - Yang, Mingshi

AU - Zhai, Guangxi

PY - 2018

Y1 - 2018

N2 - Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. This review focuses on the recent advances in biomedical application of EFM, controlled drug release from EFM and devices for producing sophisticated EFM. The processing parameters which influence the physicochemical properties of the resulting EFM are also summarized as well as scaling up techniques for mass production of EFM.

AB - Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. This review focuses on the recent advances in biomedical application of EFM, controlled drug release from EFM and devices for producing sophisticated EFM. The processing parameters which influence the physicochemical properties of the resulting EFM are also summarized as well as scaling up techniques for mass production of EFM.

KW - Biomedical application

KW - Controlled drug release

KW - Electrospinning

KW - Membranes

KW - Scaffolds

U2 - 10.1016/j.msec.2018.05.007

DO - 10.1016/j.msec.2018.05.007

M3 - Review

C2 - 29853146

AN - SCOPUS:85046632391

SN - 0921-5093

VL - 90

SP - 750

EP - 763

JO - Materials Science and Engineering: A

JF - Materials Science and Engineering: A

ER -