Bacterial infection increases risk of carcinogenesis by targeting mitochondria

Jesper A.B. Strickertsson; Claus Desler; Lene Juel Rasmussen

doi:10.1016/j.semcancer.2017.07.003

Bacterial infection increases risk of carcinogenesis by targeting mitochondria

Jesper A.B. Strickertsson, Claus Desler, Lene Juel Rasmussen^*

^*Corresponding author af dette arbejde

5 Citationer (Scopus)

Abstract

As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.

Originalsprog	Engelsk
Tidsskrift	Seminars in Cancer Biology
Vol/bind	47
Sider (fra-til)	95-100
Antal sider	6
ISSN	1044-579X
DOI	https://doi.org/10.1016/j.semcancer.2017.07.003
Status	Udgivet - dec. 2017

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1016/j.semcancer.2017.07.003

Citationsformater

@article{f145fb5a9a7d46d79c1becd55632570b,

title = "Bacterial infection increases risk of carcinogenesis by targeting mitochondria",

abstract = "As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.",

keywords = "Bacterial infection, Cancer, DNA repair, Microbiome, Mitochondrial function, Mitochondrial targeting, Mutations",

author = "Strickertsson, {Jesper A.B.} and Claus Desler and Rasmussen, {Lene Juel}",

year = "2017",

month = dec,

doi = "10.1016/j.semcancer.2017.07.003",

language = "English",

volume = "47",

pages = "95--100",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press",

}

TY - JOUR

T1 - Bacterial infection increases risk of carcinogenesis by targeting mitochondria

AU - Strickertsson, Jesper A.B.

AU - Desler, Claus

AU - Rasmussen, Lene Juel

PY - 2017/12

Y1 - 2017/12

N2 - As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.

AB - As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.

KW - Bacterial infection

KW - Cancer

KW - DNA repair

KW - Microbiome

KW - Mitochondrial function

KW - Mitochondrial targeting

KW - Mutations

U2 - 10.1016/j.semcancer.2017.07.003

DO - 10.1016/j.semcancer.2017.07.003

M3 - Review

C2 - 28754330

AN - SCOPUS:85026484129

SN - 1044-579X

VL - 47

SP - 95

EP - 100

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Bacterial infection increases risk of carcinogenesis by targeting mitochondria

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater