Bacterial infection increases risk of carcinogenesis by targeting mitochondria

Jesper A.B. Strickertsson; Claus Desler; Lene Juel Rasmussen

doi:10.1016/j.semcancer.2017.07.003

Bacterial infection increases risk of carcinogenesis by targeting mitochondria

Jesper A.B. Strickertsson, Claus Desler, Lene Juel Rasmussen^*

^*Corresponding author for this work

5 Citations (Scopus)

Abstract

As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.

Original language	English
Journal	Seminars in Cancer Biology
Volume	47
Pages (from-to)	95-100
Number of pages	6
ISSN	1044-579X
DOIs	https://doi.org/10.1016/j.semcancer.2017.07.003
Publication status	Published - Dec 2017

Keywords

Bacterial infection
Cancer
DNA repair
Microbiome
Mitochondrial function
Mitochondrial targeting
Mutations

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2017.07.003

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@article{f145fb5a9a7d46d79c1becd55632570b,

title = "Bacterial infection increases risk of carcinogenesis by targeting mitochondria",

abstract = "As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.",

keywords = "Bacterial infection, Cancer, DNA repair, Microbiome, Mitochondrial function, Mitochondrial targeting, Mutations",

author = "Strickertsson, {Jesper A.B.} and Claus Desler and Rasmussen, {Lene Juel}",

year = "2017",

month = dec,

doi = "10.1016/j.semcancer.2017.07.003",

language = "English",

volume = "47",

pages = "95--100",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press",

}

TY - JOUR

T1 - Bacterial infection increases risk of carcinogenesis by targeting mitochondria

AU - Strickertsson, Jesper A.B.

AU - Desler, Claus

AU - Rasmussen, Lene Juel

PY - 2017/12

Y1 - 2017/12

N2 - As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.

AB - As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.

KW - Bacterial infection

KW - Cancer

KW - DNA repair

KW - Microbiome

KW - Mitochondrial function

KW - Mitochondrial targeting

KW - Mutations

U2 - 10.1016/j.semcancer.2017.07.003

DO - 10.1016/j.semcancer.2017.07.003

M3 - Review

C2 - 28754330

AN - SCOPUS:85026484129

SN - 1044-579X

VL - 47

SP - 95

EP - 100

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Bacterial infection increases risk of carcinogenesis by targeting mitochondria

Abstract

Keywords

UN SDGs

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