Bacterial chitinases and chitin-binding proteins as virulence factors

Rikki Franklin Frederiksen; Dafni Katerina Paspaliari; Tanja Larsen; Birgit Groth Storgaard; Marianne Halberg Larsen; Hanne Ingmer; Monica Palcic; Jørgen Leisner

doi:10.1099/mic.0.051839-0

Bacterial chitinases and chitin-binding proteins as virulence factors

Rikki Franklin Frederiksen, Dafni Katerina Paspaliari, Tanja Larsen, Birgit Groth Storgaard, Marianne Halberg Larsen, Hanne Ingmer, Monica Palcic, Jørgen Leisner

Sektion, Food Safety and Zoonoses

112 Citationer (Scopus)

Abstract

Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

Originalsprog	Engelsk
Tidsskrift	Microbiology
Vol/bind	159
Udgave nummer	5
Sider (fra-til)	833-847
Antal sider	15
ISSN	1350-0872
DOI	https://doi.org/10.1099/mic.0.051839-0
Status	Udgivet - maj 2013

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10.1099/mic.0.051839-0

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title = "Bacterial chitinases and chitin-binding proteins as virulence factors",

abstract = "Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.",

author = "Frederiksen, {Rikki Franklin} and Paspaliari, {Dafni Katerina} and Tanja Larsen and Storgaard, {Birgit Groth} and Larsen, {Marianne Halberg} and Hanne Ingmer and Monica Palcic and J{\o}rgen Leisner",

year = "2013",

month = may,

doi = "10.1099/mic.0.051839-0",

language = "English",

volume = "159",

pages = "833--847",

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TY - JOUR

T1 - Bacterial chitinases and chitin-binding proteins as virulence factors

AU - Frederiksen, Rikki Franklin

AU - Paspaliari, Dafni Katerina

AU - Larsen, Tanja

AU - Storgaard, Birgit Groth

AU - Larsen, Marianne Halberg

AU - Ingmer, Hanne

AU - Palcic, Monica

AU - Leisner, Jørgen

PY - 2013/5

Y1 - 2013/5

N2 - Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

AB - Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

U2 - 10.1099/mic.0.051839-0

DO - 10.1099/mic.0.051839-0

M3 - Journal article

C2 - 23519157

SN - 1350-0872

VL - 159

SP - 833

EP - 847

JO - Microbiology

JF - Microbiology

IS - 5

ER -

Bacterial chitinases and chitin-binding proteins as virulence factors

Abstract

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