Bacterial chitinases and chitin-binding proteins as virulence factors

Rikki Franklin Frederiksen; Dafni Katerina Paspaliari; Tanja Larsen; Birgit Groth Storgaard; Marianne Halberg Larsen; Hanne Ingmer; Monica Palcic; Jørgen Leisner

doi:10.1099/mic.0.051839-0

Bacterial chitinases and chitin-binding proteins as virulence factors

Rikki Franklin Frederiksen, Dafni Katerina Paspaliari, Tanja Larsen, Birgit Groth Storgaard, Marianne Halberg Larsen, Hanne Ingmer, Monica Palcic, Jørgen Leisner

Food Safety and Zoonoses

112 Citations (Scopus)

Abstract

Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

Original language	English
Journal	Microbiology
Volume	159
Issue number	5
Pages (from-to)	833-847
Number of pages	15
ISSN	1350-0872
DOIs	https://doi.org/10.1099/mic.0.051839-0
Publication status	Published - May 2013

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abstract = "Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.",

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AU - Frederiksen, Rikki Franklin

AU - Paspaliari, Dafni Katerina

AU - Larsen, Tanja

AU - Storgaard, Birgit Groth

AU - Larsen, Marianne Halberg

AU - Ingmer, Hanne

AU - Palcic, Monica

AU - Leisner, Jørgen

PY - 2013/5

Y1 - 2013/5

N2 - Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

AB - Bacterial chitinases (EC 3.2.1.14) and chitin-binding proteins (CBPs) play a fundamental role in the degradation of the ubiquitous biopolymer chitin, and the degradation products serve as an important nutrient source for marine- and soil-dwelling bacteria. However, it has recently become clear that representatives of both Gram-positive and Gram-negative bacterial pathogens encode chitinases and CBPs that support infection of non-chitinous mammalian hosts. This review addresses this biological role of bacterial chitinases and CBPs in terms of substrate specificities, regulation, secretion and involvement in cellular and animal infection.

U2 - 10.1099/mic.0.051839-0

DO - 10.1099/mic.0.051839-0

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VL - 159

SP - 833

EP - 847

JO - Microbiology

JF - Microbiology

IS - 5

ER -

Bacterial chitinases and chitin-binding proteins as virulence factors

Abstract

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