Aging and drug discovery

Daniela Bakula; Alexander M. Aliper; Polina Mamoshina; Michael A. Petr; Amanuel Teklu; Joseph A. Baur; Judith Campisi; Collin Y. Ewald; Anastasia Georgievskaya; Vadim N. Gladyshev; Olga Kovalchuk; Dudley W. Lamming; Martijn S. Luijsterburg; Alejandro Martín-Montalvo; Stuart Maudsley; Garik V. Mkrtchyan; Alexey Moskalev; S. Jay Olshansky; Ivan V. Ozerov; Alexander Pickett; Michael Ristow; Alex Zhavoronkov; Morten Scheibye-Knudsen

doi:10.18632/aging.101646

Aging and drug discovery

Daniela Bakula, Alexander M. Aliper, Polina Mamoshina, Michael A. Petr, Amanuel Teklu, Joseph A. Baur, Judith Campisi, Collin Y. Ewald, Anastasia Georgievskaya, Vadim N. Gladyshev, Olga Kovalchuk, Dudley W. Lamming, Martijn S. Luijsterburg, Alejandro Martín-Montalvo, Stuart Maudsley, Garik V. Mkrtchyan, Alexey Moskalev, S. Jay Olshansky, Ivan V. Ozerov, Alexander PickettMichael Ristow, Alex Zhavoronkov, Morten Scheibye-Knudsen^*

^*Corresponding author af dette arbejde

10 Citationer (Scopus)

45 Downloads (Pure)

Abstract

Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

Originalsprog	Engelsk
Tidsskrift	Aging
Vol/bind	10
Udgave nummer	11
Sider (fra-til)	3079-3088
Antal sider	10
ISSN	1945-4589
DOI	https://doi.org/10.18632/aging.101646
Status	Udgivet - 2018

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10.18632/aging.101646Licens: CC BY

Aging and drug discoveryForlagets udgivne version, 362 KBLicens: CC BY

Citationsformater

Bakula, D., Aliper, A. M., Mamoshina, P., Petr, M. A., Teklu, A., Baur, J. A., Campisi, J., Ewald, C. Y., Georgievskaya, A., Gladyshev, V. N., Kovalchuk, O., Lamming, D. W., Luijsterburg, M. S., Martín-Montalvo, A., Maudsley, S., Mkrtchyan, G. V., Moskalev, A., Jay Olshansky, S., Ozerov, I. V., ... Scheibye-Knudsen, M. (2018). Aging and drug discovery. Aging, 10(11), 3079-3088. https://doi.org/10.18632/aging.101646

Bakula, D, Aliper, AM, Mamoshina, P, Petr, MA , Teklu, A, Baur, JA, Campisi, J, Ewald, CY, Georgievskaya, A, Gladyshev, VN, Kovalchuk, O, Lamming, DW, Luijsterburg, MS, Martín-Montalvo, A, Maudsley, S, Mkrtchyan, GV, Moskalev, A, Jay Olshansky, S, Ozerov, IV, Pickett, A, Ristow, M, Zhavoronkov, A & Scheibye-Knudsen, M 2018, 'Aging and drug discovery', Aging, bind 10, nr. 11, s. 3079-3088. https://doi.org/10.18632/aging.101646

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title = "Aging and drug discovery",

abstract = "Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.",

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author = "Daniela Bakula and Aliper, {Alexander M.} and Polina Mamoshina and Petr, {Michael A.} and Amanuel Teklu and Baur, {Joseph A.} and Judith Campisi and Ewald, {Collin Y.} and Anastasia Georgievskaya and Gladyshev, {Vadim N.} and Olga Kovalchuk and Lamming, {Dudley W.} and Luijsterburg, {Martijn S.} and Alejandro Mart{\'i}n-Montalvo and Stuart Maudsley and Mkrtchyan, {Garik V.} and Alexey Moskalev and {Jay Olshansky}, S. and Ozerov, {Ivan V.} and Alexander Pickett and Michael Ristow and Alex Zhavoronkov and Morten Scheibye-Knudsen",

year = "2018",

doi = "10.18632/aging.101646",

language = "English",

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T1 - Aging and drug discovery

AU - Bakula, Daniela

AU - Aliper, Alexander M.

AU - Mamoshina, Polina

AU - Petr, Michael A.

AU - Teklu, Amanuel

AU - Baur, Joseph A.

AU - Campisi, Judith

AU - Ewald, Collin Y.

AU - Georgievskaya, Anastasia

AU - Gladyshev, Vadim N.

AU - Kovalchuk, Olga

AU - Lamming, Dudley W.

AU - Luijsterburg, Martijn S.

AU - Martín-Montalvo, Alejandro

AU - Maudsley, Stuart

AU - Mkrtchyan, Garik V.

AU - Moskalev, Alexey

AU - Jay Olshansky, S.

AU - Ozerov, Ivan V.

AU - Pickett, Alexander

AU - Ristow, Michael

AU - Zhavoronkov, Alex

AU - Scheibye-Knudsen, Morten

PY - 2018

Y1 - 2018

N2 - Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

AB - Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

KW - Aging

KW - Drug discovery

U2 - 10.18632/aging.101646

DO - 10.18632/aging.101646

M3 - Journal article

C2 - 30425188

AN - SCOPUS:85058128265

SN - 1945-4589

VL - 10

SP - 3079

EP - 3088

JO - Aging

JF - Aging

IS - 11

ER -

Aging and drug discovery

Abstract

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