A primer to nutritional metabolomics by NMR spectroscopy and chemometrics

Francesco Savorani; Morten Arendt Rasmussen; Mette Skau Mikkelsen; Soren Balling Engelsen

doi:10.1016/j.foodres.2012.12.025

A primer to nutritional metabolomics by NMR spectroscopy and chemometrics

Francesco Savorani, Morten Arendt Rasmussen, Mette Skau Mikkelsen, Soren Balling Engelsen

68 Citationer (Scopus)

Abstract

This paper outlines the advantages and disadvantages of using high throughput NMR metabolomics for nutritional studies with emphasis on the workflow and data analytical methods for generation of new knowledge. The paper describes one-by-one the major research activities in the interdisciplinary metabolomics platform and highlights the opportunities that NMR spectra can provide in future nutrition studies. Three areas are emphasized: (1) NMR as an unbiased and non-destructive platform for providing an overview of the metabolome under investigation, (2) NMR for providing versatile information and data structures for multivariate pattern recognition methods and (3) NMR for providing a unique fingerprint of the lipoprotein status of the subject. For the first time in history, by combining NMR spectroscopy and chemometrics we are able to perform inductive nutritional research as a complement to the deductive approach. (C) 2013 Elsevier Ltd. All rights reserved.

Originalsprog	Engelsk
Tidsskrift	Food Research International
Vol/bind	54
Udgave nummer	1
Sider (fra-til)	1131-1145
Antal sider	15
ISSN	0963-9969
DOI	https://doi.org/10.1016/j.foodres.2012.12.025
Status	Udgivet - 1 nov. 2013

Emneord

Chemometrics
NMR
Metabolomics
Metabonomics
Nutrition
Nutri-metabolomics

Adgang til dokumentet

10.1016/j.foodres.2012.12.025

Citationsformater

@article{72736cdccb5e45cfa12672e406661b5b,

title = "A primer to nutritional metabolomics by NMR spectroscopy and chemometrics",

abstract = "This paper outlines the advantages and disadvantages of using high throughput NMR metabolomics for nutritional studies with emphasis on the workflow and data analytical methods for generation of new knowledge. The paper describes one-by-one the major research activities in the interdisciplinary metabolomics platform and highlights the opportunities that NMR spectra can provide in future nutrition studies. Three areas are emphasized: (1) NMR as an unbiased and non-destructive platform for providing an overview of the metabolome under investigation, (2) NMR for providing versatile information and data structures for multivariate pattern recognition methods and (3) NMR for providing a unique fingerprint of the lipoprotein status of the subject. For the first time in history, by combining NMR spectroscopy and chemometrics we are able to perform inductive nutritional research as a complement to the deductive approach.",

keywords = "Chemometrics, NMR, Metabolomics, Metabonomics, Nutrition, Nutri-metabolomics",

author = "Francesco Savorani and Rasmussen, {Morten Arendt} and Mikkelsen, {Mette Skau} and Engelsen, {Soren Balling}",

year = "2013",

month = nov,

day = "1",

doi = "10.1016/j.foodres.2012.12.025",

language = "English",

volume = "54",

pages = "1131--1145",

journal = "Food Research International",

issn = "0963-9969",

publisher = "Pergamon Press",

number = "1",

}

TY - JOUR

T1 - A primer to nutritional metabolomics by NMR spectroscopy and chemometrics

AU - Savorani, Francesco

AU - Rasmussen, Morten Arendt

AU - Mikkelsen, Mette Skau

AU - Engelsen, Soren Balling

PY - 2013/11/1

Y1 - 2013/11/1

N2 - This paper outlines the advantages and disadvantages of using high throughput NMR metabolomics for nutritional studies with emphasis on the workflow and data analytical methods for generation of new knowledge. The paper describes one-by-one the major research activities in the interdisciplinary metabolomics platform and highlights the opportunities that NMR spectra can provide in future nutrition studies. Three areas are emphasized: (1) NMR as an unbiased and non-destructive platform for providing an overview of the metabolome under investigation, (2) NMR for providing versatile information and data structures for multivariate pattern recognition methods and (3) NMR for providing a unique fingerprint of the lipoprotein status of the subject. For the first time in history, by combining NMR spectroscopy and chemometrics we are able to perform inductive nutritional research as a complement to the deductive approach.

AB - This paper outlines the advantages and disadvantages of using high throughput NMR metabolomics for nutritional studies with emphasis on the workflow and data analytical methods for generation of new knowledge. The paper describes one-by-one the major research activities in the interdisciplinary metabolomics platform and highlights the opportunities that NMR spectra can provide in future nutrition studies. Three areas are emphasized: (1) NMR as an unbiased and non-destructive platform for providing an overview of the metabolome under investigation, (2) NMR for providing versatile information and data structures for multivariate pattern recognition methods and (3) NMR for providing a unique fingerprint of the lipoprotein status of the subject. For the first time in history, by combining NMR spectroscopy and chemometrics we are able to perform inductive nutritional research as a complement to the deductive approach.

KW - Chemometrics

KW - NMR

KW - Metabolomics

KW - Metabonomics

KW - Nutrition

KW - Nutri-metabolomics

U2 - 10.1016/j.foodres.2012.12.025

DO - 10.1016/j.foodres.2012.12.025

M3 - Journal article

SN - 0963-9969

VL - 54

SP - 1131

EP - 1145

JO - Food Research International

JF - Food Research International

IS - 1

ER -

A primer to nutritional metabolomics by NMR spectroscopy and chemometrics

Abstract

Emneord

Adgang til dokumentet

Fingeraftryk

Citationsformater