The HETE Is on FFAR1 and Pancreatic Islet Cells

Mette Trauelsen; Michael Lückmann; Thomas M Frimurer; Thue W Schwartz

doi:10.1016/j.cmet.2018.01.006

The HETE Is on FFAR1 and Pancreatic Islet Cells

Mette Trauelsen, Michael Lückmann, Thomas M Frimurer, Thue W Schwartz

6 Citationer (Scopus)

Abstract

It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate that glucose-induced 20-hydroxyeicosatetraenoic acid (20-HETE) amplifies insulin secretion through autocrine activation of FFAR1.

Originalsprog	Engelsk
Tidsskrift	Cell Metabolism
Vol/bind	27
Udgave nummer	2
Sider (fra-til)	273-275
Antal sider	3
ISSN	1550-4131
DOI	https://doi.org/10.1016/j.cmet.2018.01.006
Status	Udgivet - 2018

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10.1016/j.cmet.2018.01.006

http://www.cell.com/article/S155041311830055X/pdf

Citationsformater

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abstract = "It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate that glucose-induced 20-hydroxyeicosatetraenoic acid (20-HETE) amplifies insulin secretion through autocrine activation of FFAR1.",

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AU - Trauelsen, Mette

AU - Lückmann, Michael

AU - Frimurer, Thomas M

AU - Schwartz, Thue W

PY - 2018

Y1 - 2018

N2 - It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate that glucose-induced 20-hydroxyeicosatetraenoic acid (20-HETE) amplifies insulin secretion through autocrine activation of FFAR1.

AB - It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate that glucose-induced 20-hydroxyeicosatetraenoic acid (20-HETE) amplifies insulin secretion through autocrine activation of FFAR1.

KW - Journal Article

U2 - 10.1016/j.cmet.2018.01.006

DO - 10.1016/j.cmet.2018.01.006

M3 - Journal article

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VL - 27

SP - 273

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JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

The HETE Is on FFAR1 and Pancreatic Islet Cells

Abstract

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