Mads Gyrd-Hansen

Publikation

Publikationer pr. år 2001 2004 2006 2007 2013 2014 2015

• 21 Tidsskriftartikel
• 2 Review

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2015

  A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

  Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N., & 8 flereMurphy, J. M., Gyrd-Hansen, M., Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 mar. 2015, I: Nature Communications. 6, 13 s., 6442.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Receptor-Interacting Protein Serine-Threonine Kinases 100%
  • inhibitors 82%
  • Protein Kinase Inhibitors 75%
  • Protein Kinases 65%
  • proteins 56%
  61 Citationer (Scopus)
• 2014

  Met1-linked Ubiquitination in Immune Signalling

  Fiil, B. K. & Gyrd-Hansen, M., 1 okt. 2014, I: F E B S Journal. 81, 19, s. 4337-50 14 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Ubiquitination 100%
  • Ubiquitin 92%
  • Modification 51%
  • Methionine 31%
  • Post Translational Protein Processing 31%
  41 Citationer (Scopus)

• Molecular basis and regulation of OTULIN-LUBAC interaction

  Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, B. K., Keusekotten, K., Mailand, N., Freund, S. M. V., Gyrd-Hansen, M. & Komander, D., 8 maj 2014, I: Molecular Cell. 54, 3, s. 335-348 14 s.

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  • Ubiquitin 100%
  • Deubiquitinating Enzymes 34%
  • Phosphorylation 34%
  • Magnetic Resonance Spectroscopy 20%
  • Transcription Factors 18%
  108 Citationer (Scopus)

  1638 Downloads (Pure)

• XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

  Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, M. & Jost, P. J., 26 jun. 2014, I: Cell Reports. 7, 6, s. 1796-1808

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  • X-Linked Inhibitor of Apoptosis Protein 100%
  • Lymphoproliferative Syndrome, X-Linked, 2 82%
  • Inflammasomes 80%
  • Cell Death 71%
  • Interleukin-1 40%
  147 Citationer (Scopus)
• 2013

  Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

  Damgaard, R. B., Fiil, B. K., Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, S., Jost, P. J., Ehl, S., Mailand, N. & Gyrd-Hansen, M., aug. 2013, I: E M B O Journal. 5, s. 1278-1295 18 s.

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  • Lymphoproliferative Syndrome, X-Linked, 2 100%
  • Mutation 54%
  • Apoptosis 39%
  • Pattern Recognition 19%
  • Oligomerization 16%
  96 Citationer (Scopus)

• OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin

  Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, B. K., Damgaard, R. B., Gyrd-Hansen, M. & Hofmann, K., 6 jun. 2013, I: Cell. 153, 6, s. 1312-1326 15 s.

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  • Poly(I:C) 100%
  • Polyubiquitin 92%
  • Cell Death 67%
  • Ubiquitin 63%
  • Mutation 53%
  259 Citationer (Scopus)

• OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

  Fiil, B. K., Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Komander, D. & Gyrd-Hansen, M., 27 jun. 2013, I: Molecular Cell. 50, 6, s. 818-30 13 s.

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  • Polyubiquitin 100%
  • Ubiquitination 74%
  • Nod2 Signaling Adaptor Protein 66%
  • Ubiquitin 17%
  • Receptors, Tumor Necrosis Factor, Type I 12%
  144 Citationer (Scopus)

• X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

  Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M., Kohl, M., & 10 flereMeerpohl, J. J., Rodeck, B., Kolb, R., Eberl, W., Soerensen, J., von Bernuth, H., Lorenz, M., Schwarz, K-U., zur Stadt, U. & Ehl, S., 1 okt. 2013, I: Clinical Immunology. 149, 1, s. 133-141 9 s.

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  • Hemophagocytic Lymphohistiocytosis 100%
  • Apoptosis 46%
  • Splenomegaly 33%
  • Mutation 25%
  • Giardia 20%
  104 Citationer (Scopus)
• 2012

  The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

  Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W-L., Fiil, B. K., Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, S., Mailand, N., Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, M., 29 jun. 2012, I: Molecular Cell. 46, 6, s. 746-58 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Ligases 100%
  • Ubiquitin 91%
  • Innate Immunity 84%
  • Lymphoproliferative Syndrome, X-Linked, 2 80%
  • Apoptosis 55%
  242 Citationer (Scopus)
• 2011

  Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

  Damgaard, R. B. & Gyrd-Hansen, M., mar. 2011, I: Discovery Medicine. 11, 58, s. 221-31 11 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Inhibitor of Apoptosis Proteins 100%
  • Pattern Recognition Receptors 91%
  • Innate Immunity 66%
  • Inflammation 42%
  • Blau syndrome 31%
  51 Citationer (Scopus)
• 2010

  IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

  Gyrd-Hansen, M. & Meier, P., aug. 2010, I: Nature Reviews. Cancer. 10, 8, s. 561-74 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Inhibitor of Apoptosis Proteins 100%
  • Caspase Inhibitors 87%
  • NF-kappa B 77%
  • Caspases 73%
  • Mitosis 71%
  581 Citationer (Scopus)
• 2008

  IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

  Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C. A., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J. & Meier, P., 2008, I: Nature Cell Biology. 10, 11, s. 1309-17 8 s.

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  • NF-kappa B 100%
  • Ubiquitin 94%
  • Carcinogenesis 71%
  • Cell Survival 71%
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein 13%
  176 Citationer (Scopus)
• 2007

  Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

  Yde, C. W., Gyrd-Hansen, M., Lykkesfeldt, A. E., Issinger, O-G. & Stenvang, J., jun. 2007, I: Molecular Cancer Therapeutics. 6, 6, s. 1869-1876 8 s.

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  • Estrogen Receptor Modulators 100%
  • Cisplatin 70%
  • Cell Death 59%
  • Breast Neoplasms 49%
  • MCF-7 Cells 20%
  24 Citationer (Scopus)

• Heregulin-induced epigenetic regulation of the utrophin-A promoter.

  Basu, U., Gyrd-Hansen, M., Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, M. & Khurana, T. S., 2007, I: FEBS Letters. 581, 22, s. 4153-8 5 s.

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  • Utrophin 100%
  • Neuregulin-1 90%
  • Neuromuscular 89%
  • Effector 69%
  • Histone 68%
  13 Citationer (Scopus)
• 2006

  Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9

  Gyrd-Hansen, M., Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jaattela, M., 2006, I: Molecular and Cellular Biology. 26, 21, s. 7880-7891 11 s.

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  87 Citationer (Scopus)

• Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

  Gyrd-Hansen, M., Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jäättelä, M., 2006, I: Molecular and Cellular Biology. 26, 21, s. 7880-91 11 s.

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  • Apoptosomes 100%
  • Caspase 9 70%
  • Cell Death 47%
  • Effector Caspases 23%
  • Caspase 8 17%
  87 Citationer (Scopus)
• 2004

  Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.

  Gyrd-Hansen, M., Nylandsted, J. & Jäättelä, M., 2004, I: Cell Cycle. 3, 12, s. 1484-5 1 s.

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  • HSP70 Heat-Shock Proteins 100%
  • Cell Survival 62%
  • Membranes 36%
  • Cell Death 31%
  • Cathepsins 27%
  78 Citationer (Scopus)

• Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.

  Nylandsted, J., Gyrd-Hansen, M., Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. & Jäättelä, M., 2004, I: Journal of Experimental Medicine. 200, 4, s. 425-435 11 s.

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  • HSP70 Heat-Shock Proteins 100%
  • Cell Survival 62%
  • Membranes 48%
  • Lysosomes 22%
  • Caspases 15%
  415 Citationer (Scopus)

• JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

  Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, M., Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, I: Cell Death and Differentiation. 11, 3, s. 301-13 12 s.

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  • Cathepsins 100%
  • Caspases 75%
  • Peptide Hydrolases 62%
  • Cell Death 56%
  • JNK Mitogen-Activated Protein Kinases 55%
  53 Citationer (Scopus)

• Sensitization to the lysosomal cell death pathway upon immortalization and transformation.

  Fehrenbacher, N., Gyrd-Hansen, M., Poulsen, B., Felbor, U., Kallunki, T., Boes, M., Weber, E., Leist, M. & Jäättelä, M., 2004, I: Cancer Research. 64, 15, s. 5301-10 9 s.

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  • Cathepsins 100%
  • Cathepsin B 96%
  • Cell Death 70%
  • Fibroblasts 69%
  • Cysteine 52%
  118 Citationer (Scopus)
• 2003

  Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.

  Lademann, U., Cain, K., Gyrd-Hansen, M., Brown, D., Peters, D. & Jäättelä, M., 2003, I: Molecular and Cellular Biology. 23, 21, s. 7829-37 8 s.

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  • Apoptosomes 100%
  • Caspases 62%
  • Inhibitor of Apoptosis Proteins 51%
  • Cytochromes c 40%
  • aposome 24%
  43 Citationer (Scopus)
• 2002

  Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.

  Gyrd-Hansen, M., Krag, T. O. B., Rosmarin, A. G. & Khurana, T. S., 2002, I: Journal of the Neurological Sciences. 197, 1-2, s. 27-35 8 s.

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  • Utrophin 100%
  • Proto-Oncogene Proteins c-ets 99%
  • Dystrophin 26%
  • Neuregulin-1 20%
  • Duchenne Muscular Dystrophy 16%
  21 Citationer (Scopus)
• 2001

  Harnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.

  Krag, T. O., Gyrd-Hansen, M. & Khurana, T. S., 2001, I: Acta Physiologica (Print Edition). 171, 3, s. 349-58 9 s.

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  • Utrophin 100%
  • Dystrophin 79%
  • Duchenne Muscular Dystrophy 75%
  • dystrobrevin 14%
  • Chromosomes, Human, Pair 18 10%
  17 Citationer (Scopus)