@article{a3916070224e11ddbc23000ea68e967b,
title = "Heregulin-induced epigenetic regulation of the utrophin-A promoter.",
abstract = "Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utrophin-A promoter activation. We demonstrate that heregulin activated MSK1/2 and phosphorylated histone H3 at serine 10 in cultured C2C12 muscle cells, in an ERK-dependent manner. MSK1/2 inhibition suppressed heregulin-mediated utrophin-A activation. MSK1 over-expression potentiated heregulin-mediated utrophin-A activation and chromatin remodeling at the utrophin-A promoter. These results identify MSK1/2 as key effectors modulating utrophin-A expression as well as identify novel targets for DMD therapy.",
author = "Utpal Basu and Mads Gyrd-Hansen and Baby, {Santhosh M} and Olga Lozynska and Krag, {Thomas O B} and Jensen, {Claus J} and Morten Fr{\"o}din and Khurana, {Tejvir S}",
note = "Keywords: Animals; Cells, Cultured; Chromatin Assembly and Disassembly; Enzyme Activation; Epigenesis, Genetic; Histones; Mice; Models, Genetic; Muscle Cells; Neuregulin-1; Phosphorylation; Promoter Regions (Genetics); Ribosomal Protein S6 Kinases, 90-kDa; Utrophin",
year = "2007",
doi = "10.1016/j.febslet.2007.07.021",
language = "English",
volume = "581",
pages = "4153--8",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "22",
}