IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

TY - JOUR

T1 - IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

AU - Gyrd-Hansen, Mads

AU - Meier, Pascal

N1 - Keywords: Animals; Apoptosis; Caspases; Humans; Inflammation; Inhibitor of Apoptosis Proteins; Lymphoma, B-Cell, Marginal Zone; NF-kappa B; Neoplasm Metastasis; Neoplasms; Signal Transduction; Toll-Like Receptors; Ubiquitin

PY - 2010/8

Y1 - 2010/8

N2 - The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis.

AB - The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis.

U2 - 10.1038/nrc2889

DO - 10.1038/nrc2889

M3 - Journal article

C2 - 20651737

SN - 1474-175X

VL - 10

SP - 561

EP - 574

JO - Nature Reviews. Cancer

JF - Nature Reviews. Cancer

IS - 8

ER -