Judith Margarete Gottwein

Publikation

Publikationer pr. år 2008 2013 2014 2019

• 32 Tidsskriftartikel
• 10 Patent

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

  Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J., & 1 flereGottwein, J. M., sep. 2019, I: Hepatology. 70, 3, s. 771-787 17 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Protease Inhibitors 100%
  • Hepacivirus 89%
  • Genotype 69%
  • MK-5172 42%
  • voxilaprevir 33%
  12 Citationer (Scopus)

  19 Downloads (Pure)

• HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

  Pham, L. V., Jensen, S. B., Fahnøe, U., Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez, S., Humes, D., Serre, S. B. N., Schønning, K., Bukh, J. & Gottwein, J. M., mar. 2019, I: Journal of Hepatology. 70, 3, s. 388-397

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  • voxilaprevir 100%
  • ABT-493 96%
  • Protease Inhibitors 85%
  • Hepacivirus 76%
  • Simeprevir 66%
  17 Citationer (Scopus)
• 2018

  Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

  Galli, A., Mens, H., Gottwein, J. M., Gerstoft, J. & Bukh, J., 1 dec. 2018, I: Scientific Reports. 8, 1, 13 s., 4619.

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  • Ribavirin 100%
  • Hepacivirus 82%
  • Antiviral Agents 75%
  • Cell Culture Techniques 67%
  • Adenosine Kinase 16%
  16 Citationer (Scopus)

  56 Downloads (Pure)

• Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants

  Gottwein, J. M., Pham, L. V., Mikkelsen, L. S., Ghanem, L., Ramirez, S., Scheel, T. K. H., Carlsen, T. H. R. & Bukh, J., apr. 2018, I: Gastroenterology. 154, 5, s. 1435-1448 14 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Hepacivirus 100%
  • pibrentasvir 98%
  • Genotype 77%
  • Amino Acid Substitution 63%
  • velpatasvir 53%
  55 Citationer (Scopus)

• HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

  Pham, L., Ramirez Almeida, S., Gottwein, J. M., Fahnøe, U., Li, Y., Pedersen, J. & Bukh, J., jun. 2018, I: Gastroenterology. 154, 8, s. 2194-2208.e12

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  • pibrentasvir 100%
  • velpatasvir 89%
  • Sofosbuvir 72%
  • Hepacivirus 46%
  • Cell Culture Techniques 37%
  27 Citationer (Scopus)

• High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

  Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., 2018, I: Scientific Reports. 8, 1, 13 s., 17505.

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  • Bioreactors 100%
  • Hepacivirus 77%
  • Antiviral Agents 71%
  • Cell Count 62%
  • Cell Culture Techniques 21%
  2 Citationer (Scopus)

  53 Downloads (Pure)

• Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

  Humes, D., Ramirez, S., Jensen, T. B., Li, Y. P., Gottwein, J. M. & Bukh, J., 2018, I: Virology. 522, s. 177-192 16 s.

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  • Thumb 100%
  • Hepacivirus 81%
  • Cell Culture Techniques 67%
  • Genotype 63%
  • Clone Cells 46%
  2 Citationer (Scopus)
• 2017

  Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors

  Pham, L. V., Ramirez Almeida, S., Carlsen, T. H. R., Li, Y-P., Gottwein, J. M. & Bukh, J., 2017, I: Antimicrobial Agents and Chemotherapy. 61, 6, 19 s., e00037-17.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Hepatitis Viruses 100%
  • Protease Inhibitors 81%
  • Genotype 56%
  • Hepacivirus 32%
  • Antiviral Agents 30%
  9 Citationer (Scopus)
• 2016

  Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

  Ramirez Almeida, S., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., nov. 2016, I: Gastroenterology. 151, 5, s. 973-985.e2

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  • Sofosbuvir 100%
  • Licensure 74%
  • Hepacivirus 63%
  • Cell Culture Techniques 52%
  • Genotype 48%
  52 Citationer (Scopus)
• 2015

  Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

  Mathiesen, C. K., Prentoe, J., Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, J. M. & Bukh, J., aug. 2015, I: Journal of Virology. 89, 15, s. 7758-7775 18 s.

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  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • Genotype 49%
  • mutation 47%
  • Viruses 45%
  15 Citationer (Scopus)

• Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584

  Gottwein, J. M., Scheel, T. K. H., Eugen-Olsen, J. & Bukh, J., 3 feb. 2015, IPC nr. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patentnr. WO2008/125117, 23 okt. 2008, Prioritetsdato 11 apr. 2008, Prioritetsnr. PCT/DK2008/050083

  Publikation: Patent

  • Hepatitis C 100%
  • Cell Culture Techniques 74%
  • Genotype 69%
  • Viruses 65%
  • Hepacivirus 45%

• Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398

  Gottwein, J. M., Scheel, T. K. H., Purcell, R. E. & Bukh, J., 3 feb. 2015, IPC nr. C07H 21/04 (20060101); C07H 21/02 (20060101), Patentnr. WO2011/038737, 26 jul. 2012, Prioritetsdato 16 sep. 2010, Prioritetsnr. PCT/DK2010/050236

  Publikation: Patent

  • Hepatovirus 100%
  • Nucleic Acids 60%
  • Hepacivirus 56%
  • Genotype 43%
  • Genome 27%

• Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

  Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, S., Li, Y-P., Bukh, J. & Gottwein, J. M., 1 dec. 2015, I: Antimicrobial Agents and Chemotherapy. 59, 12, s. 7426-7436 11 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Protease Inhibitors 100%
  • Hepacivirus 89%
  • Genotype 69%
  • MK-5172 56%
  • ABT-450 26%
  29 Citationer (Scopus)
• 2014

  Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors

  Li, Y-P., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, J. M. & Bukh, J., mar. 2014, I: Gastroenterology. 146, 3, s. 812-821.e4 14 s.

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  • 5' Untranslated Regions 100%
  • Protease Inhibitors 88%
  • Hepacivirus 79%
  • Genotype 61%
  • MK-5172 50%
  48 Citationer (Scopus)

• Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653

  Gottwein, J. M., Knudsen, M. L., Scheel, T. K. H. & Bukh, J., 31 mar. 2014, IPC nr. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patentnr. WO2010/017818, 18 feb. 2010, Prioritetsdato 24 jul. 2009, Prioritetsnr. PCT/DK2009/050189

  Publikation: Patent

  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 100%
  • Hepacivirus 98%
  • Inventors 85%
  • Cell Culture Techniques 81%
  • Genotype 76%

• Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022

  Gottwein, J. M., Scheel, T. K. H., Bukh, J., Prentø, J. C. & Jensen, T. B., 8 jul. 2014, IPC nr. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patentnr. WO2010/037403, 8 apr. 2010, Prioritetsdato 5 okt. 2009, Prioritetsnr. PCT/DK2009/050263

  Publikation: Patent

  • 5' Untranslated Regions 100%
  • Hepacivirus 95%
  • Genotype 73%
  • Proteins 37%
  • Reporter Genes 34%

• Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

  Ramirez, S., Li, Y-P., Jensen, S. B., Pedersen, J., Gottwein, J. M. & Bukh, J., feb. 2014, I: Hepatology. 59, 2, s. 395-407 13 s.

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  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 100%
  • Hepacivirus 82%
  • Peptide Hydrolases 74%
  • 2'-fluoro-2'-methyl-3',5'-diisobutyryldeoxycytidine 72%
  • Cell Culture Techniques 67%
  53 Citationer (Scopus)

• Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891

  Prentø, J. C., Gottwein, J. M., Scheel, T. K. H., Bukh, J. & Jensen, T. B., 30 sep. 2014, IPC nr. C07H 21/04 (20060101); C07H 21/02 (20060101), Patentnr. WO2010/022727, 4 mar. 2010, Prioritetsdato 7 aug. 2009, Prioritetsnr. PCT/DK2009/050197

  Publikation: Patent

  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 100%
  • Inventors 85%
  • Hepacivirus 49%
  • Genotype 38%
  • Viruses 35%

• Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

  Mathiesen, C. K., Jensen, T. B., Prentoe, J., Krarup, H., Nicosia, A., Law, M., Bukh, J. & Gottwein, J. M., jun. 2014, I: Virology. 458-459, s. 190-208 19 s.

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  • Virion 100%
  • Hepacivirus 97%
  • Cell Culture Techniques 79%
  • Genotype 74%
  • Serum 47%
  10 Citationer (Scopus)
• 2013

  Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

  Gottwein, J. M., Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, T. K. H., Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, J., dec. 2013, I: Antimicrobial Agents and Chemotherapy. 57, 12, s. 6034-49 16 s.

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  • 1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea 100%
  • Protease Inhibitors 61%
  • Interferon-alpha 59%
  • Hepacivirus 55%
  • Lead 54%
  12 Citationer (Scopus)

• Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974

  Scheel, T. K. H., Gottwein, J. M., Eugen-Olsen, J. & Bukh, J., 4 jun. 2013, IPC nr. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patentnr. WO2008/125119, 23 okt. 2008, Prioritetsdato 11 apr. 2008, Prioritetsnr. PCT/DK2008/050085

  Publikation: Patent

  • Hepacivirus 100%
  • Cell Culture Techniques 82%
  • Genotype 77%
  • Viruses 71%
  • Mutation 60%

• Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

  Galli, A., Scheel, T. K. H., Prentoe, J. C., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., okt. 2013, I: The Journal of general virology. 94, Pt 10, s. 2221-35 15 s.

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  • Hepatitis C virus nucleocapsid protein 100%
  • Cell Culture Techniques 50%
  • Genotype 47%
  • Hepacivirus 41%
  • Virus Assembly 19%
  14 Citationer (Scopus)

• Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

  Gottwein, J. M., Jensen, S. B., Li, Y-P., Ghanem, L., Scheel, T. K. H., Serre, S. B. N., Mikkelsen, L. & Bukh, J., mar. 2013, I: Antimicrobial Agents and Chemotherapy. 57, 3, s. 1291-303 13 s.

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  • Protease Inhibitors 100%
  • asunaprevir 94%
  • Hepacivirus 89%
  • BMS-790052 85%
  • Genotype 69%
  29 Citationer (Scopus)

• Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706

  Scheel, T. K. H., Gottwein, J. M., Prentø, J. C., Jensen, T. B. & Bukh, J., 22 okt. 2013, IPC nr. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patentnr. WO2009/080053, 2 jul. 2009, Prioritetsdato 19 dec. 2008, Prioritetsnr. PCT/DK2008/050333

  Publikation: Patent

  • Inventors 100%
  • Hepacivirus 95%
  • Cell Culture Techniques 78%
  • Genotype 74%
  • Mutation 34%

• Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275

  Jensen, T. B., Gottwein, J. M., Scheel, T. K. H., Eugen-Olsen, J. & Bukh, J., 31 dec. 2013, IPC nr. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patentnr. WO2008/141651, 27 nov. 2008, Prioritetsdato 19 maj 2008, Prioritetsnr. PCT/DK2008/050113

  Publikation: Patent

  • Hepacivirus 100%
  • Cell Culture Techniques 82%
  • Genotype 77%
  • Viruses 71%
  • Inventors 28%

• Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472

  Gottwein, J. M., Scheel, T. K. H., Jensen, T. B. & Bukh, J., 29 okt. 2013, IPC nr. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patentnr. WO2009/080052, 2 jul. 2009, Prioritetsdato 19 dec. 2008, Prioritetsnr. PCT/DK2008/050332

  Publikation: Patent

  • Hepacivirus 100%
  • Inventors 86%
  • Cell Culture Techniques 82%
  • Genotype 77%
  • Reverse Genetics 71%

• Efficient cell culture system for hepatitis C virus genotype 7a: Patent #: 8,506,969

  Gottwein, J. M., Scheel, T. K. H., Jensen, T. B. & Bukh, J., 13 aug. 2013, IPC nr. A61K 39/12 (20060101); A61K 39/29 (20060101); C12Q 1/70 (20060101); C12N 15/00 (20060101); C12N 5/071 (20100101); C12N 1/20 (20060101), Patentnr. WO2010/017819, 18 feb. 2010, Prioritetsdato 31 jul. 2009, Prioritetsnr. PCT/DK2009/050193

  Publikation: Patent

  • Hepacivirus 100%
  • Cell Culture Techniques 82%
  • Genotype 77%
  • Viruses 53%
  • Inventors 43%

• Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

  Serre, S. B. N., Krarup, H. B., Bukh, J. & Gottwein, J. M., dec. 2013, I: Journal of Virology. 87, 23, s. 12776-93 18 s.

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  • Hepatitis C virus 100%
  • interferon-alpha 93%
  • interferons 78%
  • Interferon-alpha 68%
  • Hepacivirus 63%
  19 Citationer (Scopus)

• Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

  Pedersen, J. L., Carlsen, T. H. R., Prentoe, J., Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, J., Weis, N. & Bukh, J., nov. 2013, I: Hepatology. 58, 5, s. 1587-1597 11 s.

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  • Hepacivirus 100%
  • Monoclonal Antibodies 78%
  • Genotype 67%
  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 50%
  • Neutralizing Antibodies 27%
  31 Citationer (Scopus)

• Productive homologous and non-homologous recombination of hepatitis C virus in cell culture

  Scheel, T. K. H., Galli, A., Li, Y-P., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., mar. 2013, I: P L o S Pathogens. 9, 3, s. 1-12 13 s., e1003228.

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  • Hepatitis C virus 100%
  • homologous recombination 79%
  • Homologous Recombination 77%
  • Genetic Recombination 66%
  • Hepacivirus 63%
  28 Citationer (Scopus)

• Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

  Gottwein, J. M. & Bukh, J., 1 sep. 2013, I: Nature Reviews. Gastroenterology & Hepatology. 10, 9, s. 508-9 2 s.

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  • Hepatitis 100%
  • Cell Culture Techniques 80%
  • Vaccines 79%
  • Antigens 67%
  • Cancer Vaccines 64%
  9 Citationer (Scopus)
• 2012

  Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

  Scheel, T. K. H., Prentoe, J., Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., maj 2012, I: P L o S Pathogens. 8, 5, s. 1-16 17 s., e1002696.

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  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • cell culture 54%
  • Cell Culture Techniques 52%
  • Genotype 49%
  33 Citationer (Scopus)

• Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

  Saeed, M., Scheel, T. K. H., Gottwein, J. M., Marukian, S., Dustin, L. B., Bukh, J. & Rice, C. M., okt. 2012, I: Antimicrobial Agents and Chemotherapy. 56, 10, s. 5365-73 9 s.

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  • Replicon 100%
  • Hepacivirus 73%
  • Hepatocellular Carcinoma 63%
  • Genotype 56%
  • antibiotic G 418 30%
  99 Citationer (Scopus)

• Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

  Li, Y-P., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, J. M. & Bukh, J., 27 nov. 2012, I: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, s. 19757-62 6 s.

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  • Hepacivirus 100%
  • Genotype 77%
  • Mutation 30%
  • Genome 27%
  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 25%
  88 Citationer (Scopus)

• Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

  Li, Y-P., Ramirez, S., Gottwein, J. M., Scheel, T. K. H., Mikkelsen, L., Purcell, R. H. & Bukh, J., 1 maj 2012, I: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, s. E1101-E1110 10 s.

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  • Hepacivirus 100%
  • Genotype 77%
  • Mutation 60%
  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 50%
  • hepatitis C virus NS3 protein 43%
  69 Citationer (Scopus)
• 2010

  Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

  Bidragets oversatte titel: Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studiesGottwein, J., Scheel, T., Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, J., maj 2010, I: Journal of Virology. 84, 10, s. 5277-93 17 s.

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  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • pathogenesis 62%
  • Complementary DNA 55%
  • Clone Cells 54%
  100 Citationer (Scopus)
• 2009

  DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

  Prentoe, J., Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Serre, S. & Bukh, J., 2009, I: Journal of Hepatology. 50, s. S34-S34

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• Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

  Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Lademann, J. B., Prentoe, J. C., Knudsen, M. L., Hoegh, A. M. & Bukh, J., 2009, I: Hepatology. 49, 2, s. 364-77 13 s.

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  • CD36 Antigens 100%
  • Hepacivirus 64%
  • Antiviral Agents 59%
  • Cell Culture Techniques 52%
  • Genotype 49%
  281 Citationer (Scopus)

• MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

  Gottwein, J. M., Lademann, J. B., Scheel, T. K. H., Jensen, T. B., Prentoe, J. C. & Bukh, J., 2009, I: Journal of Hepatology. 50, s. S33-S33

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
• 2008

  Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.

  Gottwein, J. M. & Bukh, J., 2008, I: Advances in Virus Research. 71, s. 51-133 82 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Life Cycle Stages 100%
  • Hepacivirus 86%
  • Cell Culture Techniques 70%
  • Genotype 39%
  • Virion 35%
  83 Citationer (Scopus)

• Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

  Scheel, T. K. H., Gottwein, J. M., Jensen, T. B., Prentø, J. C., Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, J., 2008, I: Proceedings of the National Academy of Science of the United States of America. 105, 3, s. 997-1002 5 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  149 Citationer (Scopus)

• Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

  Jensen, T. B., Gottwein, J. M., Scheel, T. K. H., Høgh, A. M., Eugen-Olsen, J. & Bukh, J., 2008, I: Journal of Infectious Diseases. 198, 12, s. 1756-1765 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Infection Control 100%
  • Neutralizing Antibodies 98%
  • Hepacivirus 91%
  • Cell Culture Techniques 75%
  • Genotype 70%
  87 Citationer (Scopus)