Jesper M. Mathiesen

Publikation

Publikationer pr. år 2003 2005 2006 2010 2011 2012 2014 2019 2019

• 24 Tidsskriftartikel
• 1 Bidrag til bog/antologi
• 1 Kommentar/debat
• 1 Konferenceabstrakt i tidsskrift
• 1 Mere
  • 1 Kort undersøgelse

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  Author Correction: Structural insights into the activation of metabotropic glutamate receptors (Nature, (2019), 566, 7742, (79-84), 10.1038/s41586-019-0881-4)

  Koehl, A., Hu, H., Feng, D., Sun, B., Zhang, Y., Robertson, M. J., Chu, M., Kobilka, T. S., Laeremans, T., Steyaert, J., Tarrasch, J., Dutta, S., Fonseca, R., Weis, W. I., Mathiesen, J. M., Skiniotis, G. & Kobilka, B. K., 14 mar. 2019, I: Nature. 567, 7747, s. E10

  Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review

  • Metabotropic Glutamate Receptors 100%
  2 Citationer (Scopus)

• Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

  Gaiser, B. I., Danielsen, M., Marcher-Rørsted, E., Røpke Jørgensen, K., Wróbel, T. M., Frykman, M., Johansson, H., Bräuner-Osborne, H., Gloriam, D. E., Mathiesen, J. M. & Sejer Pedersen, D., 12 sep. 2019, I: Journal of Medicinal Chemistry. 62, 17, s. 7806-7839 34 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Adrenergic Receptors 100%
  • Binding Sites 80%
  • Ligands 74%
  • Binding Site 73%
  • Ligand 45%
  3 Citationer (Scopus)

• Structural insights into the activation of metabotropic glutamate receptors

  Koehl, A., Hu, H., Feng, D., Sun, B., Zhang, Y., Robertson, M. J., Chu, M., Kobilka, T. S., Laermans, T., Steyaert, J., Tarrasch, J., Dutta, S., Fonseca, R., Weis, W. I., Mathiesen, J. M., Skiniotis, G. & Kobilka, B. K., 7 feb. 2019, I: Nature. 566, 7742, s. 79-84 6 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Droseraceae 100%
  • Metabotropic Glutamate Receptors 66%
  • Cysteine 50%
  • Metabotropic Glutamate 5 Receptor 26%
  • X Ray Crystallography 24%
  95 Citationer (Scopus)

• Structural Insights into the Process of GPCR-G Protein Complex Formation

  Liu, X., Xu, X., Hilger, D., Aschauer, P., Tiemann, J. K. S., Du, Y., Liu, H., Hirata, K., Sun, X., Guixa-Gonzalez, R., Mathiesen, J. M., Hildebrand, P. W. & Kobilka, B. K., 16 maj 2019, I: Cell. 177, 5, s. P1243-1251

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • GTP-Binding Proteins 100%
  • Adrenergic Receptors 95%
  • Protein 41%
  • Gs GTP-Binding Protein alpha Subunits 20%
  • Adenylyl Cyclases 12%
  38 Citationer (Scopus)
• 2018

  G_s protein peptidomimetics as allosteric modulators of the β₂-adrenergic receptor

  Boyhus, L. E., Danielsen, M., Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, K., Rasmussen, S. G. F., Mathiesen, J. M. & Pedersen, D. S., 2018, I: RSC Advances. 8, 4, s. 2219-2228 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Peptidomimetic 100%
  • Modulators 83%
  • Conformations 78%
  • Proteins 75%
  • Assays 72%
  3 Citationer (Scopus)

  53 Downloads (Pure)
• 2016

  Allosteric modulators of group III metabotropic glutamate receptors as novel therapeutics

  Mathiesen, J. M. & Teresa Ramirez, M., 19 apr. 2016, Allosteric Receptor Modulation in Drug Targeting. CRC Press, s. 207-234 28 s.

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review
• 2015

  A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

  Vedel, L., Bräuner-Osborne, H. & Mathiesen, J. M., 25 aug. 2015, I: Journal of Biomolecular Screening. 20, s. 849-857 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • EC 3.1.4.* (Phosphoric Diester Hydrolase) Inhibitor 100%
  • High-Throughput Screening Assays 93%
  • Phosphodiesterase Inhibitors 80%
  • Biosensing Techniques 80%
  • High Throughput Screening 70%
  12 Citationer (Scopus)
• 2014

  mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

  Mølck, C., Harpsøe, K., Gloriam, D. E., Mathiesen, J. M., Nielsen, S. M. & Bräuner-Osborne, H., 24 sep. 2014, I: Neurochemical Research. 39, 10, s. 1862-1875 14 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Drug Discovery 100%
  • Ligands 68%
  • Drug 51%
  • Ligand 42%
  • Application 30%
  21 Citationer (Scopus)

• Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

  Roed, S. N., Wismann, P., Underwood, C. R., Kulahin, N., Iversen, H., Cappelen, K. A., Schäffer, L., Lehtonen, J., Hecksher-Soerensen, J., Secher, A., Mathiesen, J. M., Bräuner-Osborne, H., Whistler, J. L., Knudsen, S. M. & Waldhoer, M., feb. 2014, I: Molecular and Cellular Endocrinology. 382, 2, s. 938-949 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Glucagon-Like Peptide 1 100%
  • Incretins 82%
  • Glucagon-Like Peptide-1 Receptor 81%
  • Liraglutide 60%
  • Exendin-4 56%
  87 Citationer (Scopus)
• 2013

  cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors

  Mathiesen, J. M., Vedel, L. & Bräuner-Osborne, H., 2013, I: Methods in Enzymology. 522, s. 191-207 17 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

  • Biosensing Techniques 100%
  • G-Protein-Coupled Receptors 82%
  • Cyclic AMP 80%
  • Fluorescence Resonance Energy Transfer 68%
  • Pharmacology 54%
  12 Citationer (Scopus)
• 2012

  Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

  Manglik, A., Kruse, A. C., Kobilka, T. S., Thian, F. S., Mathiesen, J. M., Sunahara, R. K., Pardo, L., Weis, W. I., Kobilka, B. K. & Granier, S., 17 maj 2012, I: Nature. 485, 7398, s. 321-326 6 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Morphinans 100%
  • Opioid Receptors 61%
  • G-Protein-Coupled Receptors 36%
  • Morphine Derivatives 32%
  • Opium 27%
  925 Citationer (Scopus)

• Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

  Mølck, C., Harpsøe, K., Gloriam, D. E., Clausen, R. P., Madsen, U., Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, J. M. & Bräuner-Osborne, H., nov. 2012, I: Molecular Pharmacology. 82, 5, s. 929-37 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Metabotropic Glutamate 5 Receptor 100%
  • pyridine 86%
  • Benzene 82%
  • Binding Sites 51%
  • Pharmacology 44%
  30 Citationer (Scopus)

• Structure-activity relationships for negative allosteric mGluR5 modulators

  Kaae, B. H., Harpsøe, K., Kvist, T., Mathiesen, J. M., Mølck, C., Gloriam, D. E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, B., Bräuner-Osborne, H., Sauerberg, P., Clausen, R. P. & Madsen, U., 5 mar. 2012, I: ChemMedChem. 7, 3, s. 440-451

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • pyridine 100%
  • Structure-Activity Relationship 90%
  • Pyridine 54%
  • 2-methyl-6-(phenylethynyl)pyridine 51%
  • 6-methyl-2-(phenylethynyl)pyridine 43%
  15 Citationer (Scopus)
• 2011

  Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

  Molck, C., Harpsoe, K., Gloriam, D. E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, R. P., Madsen, U., Nielsen, S. M., Mathiesen, J. M. & Brauner-Osborne, H., sep. 2011, I: Current Neuropharmacology. 9, s. 43-43

  Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning

• Crystal structure of the β2 adrenergic receptor-Gs protein complex

  Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., Mathiesen, J. M., Shah, S. T. A., Lyons, J. A., Caffrey, M., Gellman, S. H., Steyaert, J., Skiniotis, G., Weis, W. I., Sunahara, R. K. & Kobilka, B. K., 29 sep. 2011, I: Nature. 477, 7366, s. 549-55 7 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • G-Protein-Coupled Receptors 100%
  • Adrenergic Receptors 94%
  • Nucleotides 40%
  • Gs GTP-Binding Protein alpha Subunits 39%
  • Proteins 36%
  2005 Citationer (Scopus)
• 2010

  1,2,3-triazolyl amino acids as AMPA receptor ligands

  Stanley, N. J., Pedersen, D. S., Nielsen, B., Kvist, T., Mathiesen, J. M., Bräuner-Osborne, H., Taylor, D. K. & Abell, A. D., 15 dec. 2010, I: Bioorganic & Medicinal Chemistry Letters. 20, 24, s. 7512-7515

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • AMPA Receptors 100%
  • Glutamate Receptors 93%
  • Ligands 59%
  • Amino Acids 59%
  • Drug Discovery 43%
  30 Citationer (Scopus)

• A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

  Stanley, N. J., Hutchinson, M. R., Kvist, T., Nielsen, B., Mathiesen, J. M., Bräuner-Osborne, H., Avery, T. D., Tiekink, E. R. T., Pedersen, D. S., Irvine, R. J., Abell, A. D. & Taylor, D. K., 15 aug. 2010, I: Bioorganic & Medicinal Chemistry. 18, 16, s. 6089-6098

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Antiallodynic 100%
  • Metabotropic Receptor Agonist 97%
  • Excitatory Amino Acid Agonists 71%
  • Metabotropic Glutamate Receptors 65%
  • Neuralgia 53%
  4 Citationer (Scopus)

• Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists

  Grimstrup, M., Receveur, J. M., Rist, Ø., Frimurer, T. M., Nielsen, P. A., Mathiesen, J. M. & Högberg, T., 1 mar. 2010, I: Bioorganic and Medicinal Chemistry Letters. 20, 5, s. 1638-1641 4 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Chemoattractant 100%
  • Formyl Peptide Receptor 98%
  • imidazole 88%
  • pyrimidine 83%
  • Hydrogen Bonding 81%
  15 Citationer (Scopus)

• Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2

  Grimstrup, M., Rist, Ø., Receveur, J-M., Frimurer, T. M., Ulven, T., Mathiesen, J. M., Kostenis, E. & Högberg, T., 1 feb. 2010, I: Bioorganic & Medicinal Chemistry Letters. 20, 3, s. 1181-1185 5 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Thiazoles 100%
  • Chemoattractant 94%
  • Thiazole 71%
  • Computer Simulation 61%
  • Antagonist 59%
  14 Citationer (Scopus)
• 2009

  The C-terminal tail of CRTH2 is a key molecular determinant that constrains GalphaI- and downstream-signaling cascade activation

  Schroeder, R., Merten, N., Mathiesen, J. M., Martini, L., Letunic, A. K., Krop, F., Blaukat, A., Fang, Y., Tran, E., Ulven, T., Drewke, C., Whistler, J., Pardo, L., Gomeza, J. & Kostenis, E., 2009, I: Journal of Biological Chemistry. 284, 2, s. 1324-1336 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • GTP-Binding Proteins 100%
  • Tail 64%
  • Prostaglandins D 51%
  • Protein 41%
  • Asthma 25%
  51 Citationer (Scopus)
• 2007

  Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

  Uller, L., Mathiesen, J. M., Alenmyr, L., Korsgren, M., Ulven, T., Högberg, T., Andersson, G., Persson, C. G. A. & Kostenis, E., 1 feb. 2007, I: Respiratory Research. 8, 16

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • ramatroban 100%
  • prostaglandin D2 receptor 87%
  • Asthma 41%
  • Mucus 33%
  • Pathology 33%
  111 Citationer (Scopus)
• 2006

  6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists

  Ulven, T., Little, P. B., Receveur, J-M., Frimurer, T. M., Rist, Ø., Nørregaard, P. K., Mathiesen, J. M. & Högberg, T., 2006, I: Bioorganic & Medicinal Chemistry Letters. 16, 4, s. 1070-1075 6 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  31 Citationer (Scopus)

• Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

  Ulven, T., Receveur, J-M., Grimstrup, M., Rist, Ø., Frimurer, T. M., Gerlach, L-O., Mathiesen, J. M., Kostenis, E., Uller, L. & Högberg, T., 2006, I: Journal of Medicinal Chemistry. 49, 23, s. 6638-6641 4 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  36 Citationer (Scopus)

• On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

  Mathiesen, J. M., Christopoulos, A., Ulven, T., Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, I: Molecular Pharmacology. 69, 4, s. 1441-1453 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  43 Citationer (Scopus)

• The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation

  Mathiesen, J. M. & Ramirez, M. T., 1 jun. 2006, I: British Journal of Pharmacology. 148, 3, s. 279-290 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • metabotropic glutamate receptor 4 100%
  • Protein Kinase C 55%
  • phorbol-12-myristate 18%
  • Neurokinin-3 Receptors 17%
  • Acetates 15%
  23 Citationer (Scopus)
• 2005

  Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2

  Mathiesen, J. M., Ulven, T., Martin, L., Gerlach, L-O., Heinemann, A. & Kostenis, E., 2005, I: Molecular Pharmacology. 68, 2, s. 393-402 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  85 Citationer (Scopus)

• Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators

  Ritzén, A., Mathiesen, J. M. & Thomsen, C., 1 okt. 2005, I: Basic and Clinical Pharmacology and Toxicology. 97, 4, s. 202-213 12 s.

  Publikation: Bidrag til tidsskrift › Kort undersøgelse › peer review

  • Metabotropic Glutamate Receptors 100%
  • Pharmacology 53%
  • Physiological Role 49%
  • Distribution Function 48%
  • Huntington Disease 44%
  90 Citationer (Scopus)
• 2003

  Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

  Mathiesen, J. M., Svendsen, N., Bräuner-Osborne, H., Thomsen, C. & Ramirez, M. T., mar. 2003, I: British Journal of Pharmacology. 138, 6, s. 1026-30

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • SIB 1893 100%
  • metabotropic glutamate receptor 4 80%
  • pyridine 61%
  • 2-amino-4-phosphono-propinate 34%
  • cyclopropyl-4-phosphonophenylglycine 26%
  159 Citationer (Scopus)