1,2,3-triazolyl amino acids as AMPA receptor ligands

Nathan J. Stanley; Daniel Sejer Pedersen; Birgitte Nielsen; Trine Kvist; Jesper M Mathiesen; Hans Bräuner-Osborne; Dennis K Taylor; Andrew D Abell

doi:10.1016/j.bmcl.2010.09.139

1,2,3-triazolyl amino acids as AMPA receptor ligands

Nathan J. Stanley, Daniel Sejer Pedersen, Birgitte Nielsen, Trine Kvist, Jesper M Mathiesen, Hans Bräuner-Osborne, Dennis K Taylor, Andrew D Abell

30 Citationer (Scopus)

Abstract

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

Originalsprog	Engelsk
Tidsskrift	Bioorganic & Medicinal Chemistry Letters
Vol/bind	20
Udgave nummer	24
Sider (fra-til)	7512-7515
ISSN	0960-894X
DOI	https://doi.org/10.1016/j.bmcl.2010.09.139
Status	Udgivet - 15 dec. 2010

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10.1016/j.bmcl.2010.09.139

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title = "1,2,3-triazolyl amino acids as AMPA receptor ligands",

abstract = "The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Stanley, {Nathan J.} and Pedersen, {Daniel Sejer} and Birgitte Nielsen and Trine Kvist and Mathiesen, {Jesper M} and Hans Br{\"a}uner-Osborne and Taylor, {Dennis K} and Abell, {Andrew D}",

note = "Keywords: synthesis; glutamate receptor; triazole",

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T1 - 1,2,3-triazolyl amino acids as AMPA receptor ligands

AU - Stanley, Nathan J.

AU - Pedersen, Daniel Sejer

AU - Nielsen, Birgitte

AU - Kvist, Trine

AU - Mathiesen, Jesper M

AU - Bräuner-Osborne, Hans

AU - Taylor, Dennis K

AU - Abell, Andrew D

N1 - Keywords: synthesis; glutamate receptor; triazole

PY - 2010/12/15

Y1 - 2010/12/15

N2 - The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

AB - The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.bmcl.2010.09.139

DO - 10.1016/j.bmcl.2010.09.139

M3 - Journal article

C2 - 21036612

SN - 0960-894X

VL - 20

SP - 7512

EP - 7515

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 24

ER -

1,2,3-triazolyl amino acids as AMPA receptor ligands

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