Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Clare L Hawkins

doi:10.1038/ki.2014.256

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

6 Citationer (Scopus)

Abstract

Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

Originalsprog	Engelsk
Tidsskrift	Kidney International
Vol/bind	86
Udgave nummer	5
Sider (fra-til)	875-7
Antal sider	3
ISSN	0085-2538
DOI	https://doi.org/10.1038/ki.2014.256
Status	Udgivet - 5 nov. 2014
Udgivet eksternt	Ja

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1038/ki.2014.256

http://www.kidney-international.org/article/S0085253815304336/pdf

Citationsformater

@article{c390ea89bac449bd95e136a13b467251,

title = "Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?",

abstract = "Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.",

keywords = "Animals, Aorta, Cyanates, Endothelial Cells, Endothelium, Vascular, Humans, Male, Vasodilation, Comment, Journal Article, Research Support, Non-U.S. Gov't",

author = "Hawkins, {Clare L}",

year = "2014",

month = nov,

day = "5",

doi = "10.1038/ki.2014.256",

language = "English",

volume = "86",

pages = "875--7",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Role of cyanate in the induction of vascular dysfunction during uremia

T2 - more than protein carbamylation?

AU - Hawkins, Clare L

PY - 2014/11/5

Y1 - 2014/11/5

N2 - Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

AB - Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

KW - Animals

KW - Aorta

KW - Cyanates

KW - Endothelial Cells

KW - Endothelium, Vascular

KW - Humans

KW - Male

KW - Vasodilation

KW - Comment

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ki.2014.256

DO - 10.1038/ki.2014.256

M3 - Journal article

C2 - 25360490

SN - 0085-2538

VL - 86

SP - 875

EP - 877

JO - Kidney International

JF - Kidney International

IS - 5

ER -

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater