Parallel evolution of fish bi-modal breathing and expansion of olfactory receptor (OR) genes: toward a universal ORs nomenclature

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  • Liliana Silva
  • Tito Mendes
  • Luana Ramos
  • KU, thw266
  • Agostinho Antunes

Olfactory receptors (ORs) play a key role in the prime sensorial perception, being highly relevant for intra/interspecific interactions. ORs are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in vertebrates. However, OR repertoires remain poorly studied in fish lineages, precluding finely retracing their origin, evolution, and diversification, especially in the most basal groups. Here, we conducted an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires (2–583 genes). While the early vertebrates performed gas exchange through gills, we hypothesize that the emergence of new breathing structures (swim bladder and paired lungs) in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne molecules. Additionally, we verified that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication, likely due to regulatory mechanisms compensating the gene load excess. Finally, we identified 25 distinct OR families, allowing us to propose an updated universal nomenclature for the fish ORs.

OriginalsprogEngelsk
TidsskriftJournal of Genetics and Genomics
Vol/bind50
Udgave nummer8
Antal sider11
ISSN1673-8527
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
We would like to thank all the constructive comments and suggestions provided by the three anonymous reviewers, which greatly improved the quality of this work. We thank all the useful and constructive comments provided by colleagues of the Evolutionary Genomics and Bioinformatics Group of CIIMAR (University of Porto) on a previous version of this manuscript. This work was supported by a PhD grant from “Fundação para a Ciência e a Tecnologia” ( FCT ) (L.S.: SFRH/ BD /134565/2017; COVID/ BD /151995/2021, T.M.: SFRH/ BD /112458/2015, L.R.: SFRH/ BD /142322/2018). A.A. was partially supported by the Strategic Funding UIDB/04423/2020 and UIDP/04423/2020 through national funds provided by FCT and the European Regional Development Fund ( ERDF ) in the framework of the program PT 2020, by the European Structural and Investment Funds (ESIF) through the Competitiveness and Internationalization Operational Program – COMPETE 2020 through the FCT project PTDC/CTA- AMB /31774/2017 (POCI-01-0145- FEDER /031774/2017), and the projects Ocean3R (NORTE-01-0145-FEDER-000064) and Atlantida (NORTE-01-0145-FEDER-000040).

Funding Information:
We would like to thank all the constructive comments and suggestions provided by the three anonymous reviewers, which greatly improved the quality of this work. We thank all the useful and constructive comments provided by colleagues of the Evolutionary Genomics and Bioinformatics Group of CIIMAR (University of Porto) on a previous version of this manuscript. This work was supported by a PhD grant from “Fundação para a Ciência e a Tecnologia” (FCT) (L.S.: SFRH/BD/134565/2017; COVID/BD/151995/2021, T.M.: SFRH/BD/112458/2015, L.R.: SFRH/BD/142322/2018). A.A. was partially supported by the Strategic Funding UIDB/04423/2020 and UIDP/04423/2020 through national funds provided by FCT and the European Regional Development Fund (ERDF) in the framework of the program PT 2020, by the European Structural and Investment Funds (ESIF) through the Competitiveness and Internationalization Operational Program – COMPETE 2020 through the FCT project PTDC/CTA-AMB/31774/2017 (POCI-01-0145-FEDER/031774/2017), and the projects Ocean3R (NORTE-01-0145-FEDER-000064) and Atlantida (NORTE-01-0145-FEDER-000040).

Publisher Copyright:
© 2023

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