Z-score transformation of T-wave morphology values to a standardized scale

C. Graff; J. Nielsen; J. K. Kanters; J. Matz; S. E. Schmidt; E. Toft; J. J. Struijk

Z-score transformation of T-wave morphology values to a standardized scale

C. Graff^*, J. Nielsen, J. K. Kanters, J. Matz, S. E. Schmidt, E. Toft, J. J. Struijk

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

Original language	English
Title of host publication	Computing in Cardiology 2011, CinC 2011
Number of pages	4
Volume	38
Publication date	1 Dec 2011
Pages	737-740
Article number	6164671
ISBN (Print)	9781457706127
Publication status	Published - 1 Dec 2011
Event	Computing in Cardiology 2011, CinC 2011 - Hangzhou, China Duration: 18 Sept 2011 → 21 Sept 2011

Conference

Conference	Computing in Cardiology 2011, CinC 2011
Country/Territory	China
City	Hangzhou
Period	18/09/2011 → 21/09/2011
Sponsor	European Society of Cardiology, Zhejiang University, EMB, IEEE, Drager

Cite this

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title = "Z-score transformation of T-wave morphology values to a standardized scale",

abstract = "Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.",

author = "C. Graff and J. Nielsen and Kanters, {J. K.} and J. Matz and Schmidt, {S. E.} and E. Toft and Struijk, {J. J.}",

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T1 - Z-score transformation of T-wave morphology values to a standardized scale

AU - Graff, C.

AU - Nielsen, J.

AU - Kanters, J. K.

AU - Matz, J.

AU - Schmidt, S. E.

AU - Toft, E.

AU - Struijk, J. J.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

AB - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

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M3 - Article in proceedings

AN - SCOPUS:84859990662

SN - 9781457706127

VL - 38

SP - 737

EP - 740

BT - Computing in Cardiology 2011, CinC 2011

T2 - Computing in Cardiology 2011, CinC 2011

Y2 - 18 September 2011 through 21 September 2011

ER -

Z-score transformation of T-wave morphology values to a standardized scale

Abstract

Conference

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