Z-score transformation of T-wave morphology values to a standardized scale

C. Graff; J. Nielsen; J. K. Kanters; J. Matz; S. E. Schmidt; E. Toft; J. J. Struijk

Z-score transformation of T-wave morphology values to a standardized scale

C. Graff^*, J. Nielsen, J. K. Kanters, J. Matz, S. E. Schmidt, E. Toft, J. J. Struijk

^*Corresponding author af dette arbejde

2 Citationer (Scopus)

Abstract

Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

Originalsprog	Engelsk
Titel	Computing in Cardiology 2011, CinC 2011
Antal sider	4
Vol/bind	38
Publikationsdato	1 dec. 2011
Sider	737-740
Artikelnummer	6164671
ISBN (Trykt)	9781457706127
Status	Udgivet - 1 dec. 2011
Begivenhed	Computing in Cardiology 2011, CinC 2011 - Hangzhou, Kina Varighed: 18 sep. 2011 → 21 sep. 2011

Konference

Konference	Computing in Cardiology 2011, CinC 2011
Land/Område	Kina
By	Hangzhou
Periode	18/09/2011 → 21/09/2011
Sponsor	European Society of Cardiology, Zhejiang University, EMB, IEEE, Drager

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Citationsformater

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title = "Z-score transformation of T-wave morphology values to a standardized scale",

abstract = "Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.",

author = "C. Graff and J. Nielsen and Kanters, {J. K.} and J. Matz and Schmidt, {S. E.} and E. Toft and Struijk, {J. J.}",

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language = "English",

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note = "Computing in Cardiology 2011, CinC 2011 ; Conference date: 18-09-2011 Through 21-09-2011",

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T1 - Z-score transformation of T-wave morphology values to a standardized scale

AU - Graff, C.

AU - Nielsen, J.

AU - Kanters, J. K.

AU - Matz, J.

AU - Schmidt, S. E.

AU - Toft, E.

AU - Struijk, J. J.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

AB - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

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M3 - Article in proceedings

AN - SCOPUS:84859990662

SN - 9781457706127

VL - 38

SP - 737

EP - 740

BT - Computing in Cardiology 2011, CinC 2011

T2 - Computing in Cardiology 2011, CinC 2011

Y2 - 18 September 2011 through 21 September 2011

ER -

Z-score transformation of T-wave morphology values to a standardized scale

Abstract

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