Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure

TY - JOUR

T1 - Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure

AU - Gerlach, Stephan U

AU - Eichenlaub, Teresa

AU - Herranz, Héctor

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains controversial. Here, we use Drosophila epithelial cells to investigate the consequences of cytokinesis failure in vivo. We report that cleavage defects trigger the activation of the JNK pathway, leading to downregulation of the inhibitor of apoptosis DIAP1 and programmed cell death. Yorkie overcomes the tumor-suppressive role of JNK and induces neoplasia. Yorkie regulates the cell cycle phosphatase Cdc25/string, which drives tumorigenesis in a context of cytokinesis failure. These results highlight the functional significance of the JNK pathway in epithelial cells with defective cytokinesis and elucidate a mechanism used by emerging tumor cells to bypass this tumor-suppressive barrier and develop into tumors. Cytokinesis failure can be tumorigenic. Gerlach et al. show that JNK represses the expansion of those cells. Yorkie, the Drosophila ortholog of YAP and effector of the Hippo pathway, is able to bypass this barrier in cells with cytokinesis defects and cause neoplastic tumors.

AB - Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains controversial. Here, we use Drosophila epithelial cells to investigate the consequences of cytokinesis failure in vivo. We report that cleavage defects trigger the activation of the JNK pathway, leading to downregulation of the inhibitor of apoptosis DIAP1 and programmed cell death. Yorkie overcomes the tumor-suppressive role of JNK and induces neoplasia. Yorkie regulates the cell cycle phosphatase Cdc25/string, which drives tumorigenesis in a context of cytokinesis failure. These results highlight the functional significance of the JNK pathway in epithelial cells with defective cytokinesis and elucidate a mechanism used by emerging tumor cells to bypass this tumor-suppressive barrier and develop into tumors. Cytokinesis failure can be tumorigenic. Gerlach et al. show that JNK represses the expansion of those cells. Yorkie, the Drosophila ortholog of YAP and effector of the Hippo pathway, is able to bypass this barrier in cells with cytokinesis defects and cause neoplastic tumors.

U2 - 10.1016/j.celrep.2018.04.006

DO - 10.1016/j.celrep.2018.04.006

M3 - Journal article

C2 - 29719260

SN - 2639-1856

VL - 23

SP - 1491

EP - 1503

JO - Cell Reports

JF - Cell Reports

IS - 5

ER -