Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

TY - JOUR

T1 - Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

AU - Trinh, Thi Dieu Binh

AU - Quach, Tam T. T.

AU - Bui, Dung N.

AU - Stærk, Dan

AU - Nguyen, Lien-Hoa D.

AU - Jäger, Anna K

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7 ± 0.5 and 14.1 ± 3.5 μM, respectively

AB - Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7 ± 0.5 and 14.1 ± 3.5 μM, respectively

U2 - 10.1016/j.fitote.2017.03.003

DO - 10.1016/j.fitote.2017.03.003

M3 - Journal article

C2 - 28322990

SN - 1971-551X

VL - 118

SP - 126

EP - 131

JO - Fitoterapia

JF - Fitoterapia

ER -