Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

TY - JOUR

T1 - Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

AU - Bay-Jensen, Anne-Christine

AU - Hoegh-Madsen, Suzi

AU - Dam, Erik

AU - Henriksen, Kim

AU - Sondergaard, Bodil Cecillie

AU - Pastoureau, Philippe

AU - Qvist, Per

AU - Karsdal, Morten A

PY - 2010/2

Y1 - 2010/2

N2 - Osteoarthritis (OA) is a disease of the entire joint. Different treatment strategies for OA have been proposed and tested clinically without the desired efficacy. One reason for the scarcity of current chondroprotective agents may be the insufficient understanding of the patho-physiology of the joint and whether the joint damage is reversible or irreversible. In this review, we compile emerging data on cellular and pathological aspects of OA, and ask whether these data could give clue to when cartilage degradation is reversible and whether a point-of-no-return exists. We highlight different stages of OA, and speculate whether different intervention strategies (e.g. DMOAD vs. SMOADs) may only be efficacious at distinct stages of OA.

AB - Osteoarthritis (OA) is a disease of the entire joint. Different treatment strategies for OA have been proposed and tested clinically without the desired efficacy. One reason for the scarcity of current chondroprotective agents may be the insufficient understanding of the patho-physiology of the joint and whether the joint damage is reversible or irreversible. In this review, we compile emerging data on cellular and pathological aspects of OA, and ask whether these data could give clue to when cartilage degradation is reversible and whether a point-of-no-return exists. We highlight different stages of OA, and speculate whether different intervention strategies (e.g. DMOAD vs. SMOADs) may only be efficacious at distinct stages of OA.

KW - Antirheumatic Agents

KW - Cartilage, Articular

KW - Disease Progression

KW - Humans

KW - Joints

KW - Osteoarthritis

KW - Recovery of Function

KW - Journal Article

KW - Review

U2 - 10.1007/s00296-009-1183-1

DO - 10.1007/s00296-009-1183-1

M3 - Review

C2 - 19816688

SN - 0172-8172

VL - 30

SP - 435

EP - 442

JO - Rheumatology International

JF - Rheumatology International

IS - 4

ER -