Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

Anne-Christine Bay-Jensen; Suzi Hoegh-Madsen; Erik Dam; Kim Henriksen; Bodil Cecillie Sondergaard; Philippe Pastoureau; Per Qvist; Morten A Karsdal

doi:10.1007/s00296-009-1183-1

Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

Anne-Christine Bay-Jensen, Suzi Hoegh-Madsen, Erik Dam, Kim Henriksen, Bodil Cecillie Sondergaard, Philippe Pastoureau, Per Qvist, Morten A Karsdal

Datalogisk Institut

90 Citationer (Scopus)

Abstract

Osteoarthritis (OA) is a disease of the entire joint. Different treatment strategies for OA have been proposed and tested clinically without the desired efficacy. One reason for the scarcity of current chondroprotective agents may be the insufficient understanding of the patho-physiology of the joint and whether the joint damage is reversible or irreversible. In this review, we compile emerging data on cellular and pathological aspects of OA, and ask whether these data could give clue to when cartilage degradation is reversible and whether a point-of-no-return exists. We highlight different stages of OA, and speculate whether different intervention strategies (e.g. DMOAD vs. SMOADs) may only be efficacious at distinct stages of OA.

Originalsprog	Engelsk
Tidsskrift	Rheumatology International
Vol/bind	30
Udgave nummer	4
Sider (fra-til)	435-42
Antal sider	8
ISSN	0172-8172
DOI	https://doi.org/10.1007/s00296-009-1183-1
Status	Udgivet - feb. 2010

Adgang til dokumentet

10.1007/s00296-009-1183-1

Citationsformater

@article{c38788956f26410794e4943c530bd1d9,

title = "Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?",

abstract = "Osteoarthritis (OA) is a disease of the entire joint. Different treatment strategies for OA have been proposed and tested clinically without the desired efficacy. One reason for the scarcity of current chondroprotective agents may be the insufficient understanding of the patho-physiology of the joint and whether the joint damage is reversible or irreversible. In this review, we compile emerging data on cellular and pathological aspects of OA, and ask whether these data could give clue to when cartilage degradation is reversible and whether a point-of-no-return exists. We highlight different stages of OA, and speculate whether different intervention strategies (e.g. DMOAD vs. SMOADs) may only be efficacious at distinct stages of OA.",

keywords = "Antirheumatic Agents, Cartilage, Articular, Disease Progression, Humans, Joints, Osteoarthritis, Recovery of Function, Journal Article, Review",

author = "Anne-Christine Bay-Jensen and Suzi Hoegh-Madsen and Erik Dam and Kim Henriksen and Sondergaard, {Bodil Cecillie} and Philippe Pastoureau and Per Qvist and Karsdal, {Morten A}",

year = "2010",

month = feb,

doi = "10.1007/s00296-009-1183-1",

language = "English",

volume = "30",

pages = "435--42",

journal = "Rheumatology International",

issn = "0172-8172",