TY - JOUR
T1 - Vital Exhaustion and Incidence of Dementia
T2 - Results from the Copenhagen City Heart Study
AU - Islamoska, Sabrina
AU - Ishtiak-Ahmed, Kazi
AU - Hansen, Åse Marie
AU - Grynderup, Matias
AU - Mortensen, Erik Lykke
AU - Garde, Anne Helene
AU - Gyntelberg, Finn
AU - Prescott, Eva
AU - Török, Eszter
AU - Waldemar, Gunhild
AU - Nabe-Nielsen, Kirsten
PY - 2019
Y1 - 2019
N2 - Background: Psychological distress is potentially linked to the risk of dementia through neurologic and cardiovascular mechanisms. Vital exhaustion (VE) is a mental state of psychological distress, which could be a risk factor for dementia. Objective: To investigate whether VE is a risk factor for dementia in later life. Methods:We used data from 6,807 participants attending the third survey of the Copenhagen City Heart Study in 1991-1994. VE was assessed by 17 symptoms (score: 0-17) from the Maastricht Questionnaire. Information on dementia was obtained from national registers. Risk time for dementia was counted from five years after VE assessment for participants > 55 years at the time of VE assessment. For younger participants, risk time for dementia was counted from the year they turned 60 years and onwards. Participants were followed until 2016.We used Poisson regression to calculate incidence rate ratios (IRR) and their 95% confidence intervals (CI). Results: During an average follow-up of 10 years, 872 participants were registered with dementia. We found a doseresponse relation between the number of VE symptoms and the incidence of dementia. For every additional VE symptom, the dementia incidence increased by 2% (IRR = 1.024; 95% CI: 1.004-1.043). Adjustment for socio-demographic and healthrelated factors did not change the results substantially. Neither did stratification by age, sex, educational level, and marital status.
AB - Background: Psychological distress is potentially linked to the risk of dementia through neurologic and cardiovascular mechanisms. Vital exhaustion (VE) is a mental state of psychological distress, which could be a risk factor for dementia. Objective: To investigate whether VE is a risk factor for dementia in later life. Methods:We used data from 6,807 participants attending the third survey of the Copenhagen City Heart Study in 1991-1994. VE was assessed by 17 symptoms (score: 0-17) from the Maastricht Questionnaire. Information on dementia was obtained from national registers. Risk time for dementia was counted from five years after VE assessment for participants > 55 years at the time of VE assessment. For younger participants, risk time for dementia was counted from the year they turned 60 years and onwards. Participants were followed until 2016.We used Poisson regression to calculate incidence rate ratios (IRR) and their 95% confidence intervals (CI). Results: During an average follow-up of 10 years, 872 participants were registered with dementia. We found a doseresponse relation between the number of VE symptoms and the incidence of dementia. For every additional VE symptom, the dementia incidence increased by 2% (IRR = 1.024; 95% CI: 1.004-1.043). Adjustment for socio-demographic and healthrelated factors did not change the results substantially. Neither did stratification by age, sex, educational level, and marital status.
U2 - 10.3233/JAD-180478
DO - 10.3233/JAD-180478
M3 - Journal article
C2 - 30584138
SN - 1387-2877
VL - 67
SP - 369
EP - 379
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
ER -