Abstract
OBJECTIVE: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space.
METHODS: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space.
RESULTS: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space.
CONCLUSIONS: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space.
SIGNIFICANCE: This novel method facilitates the clinical use of MEG.
| Original language | English |
|---|---|
| Journal | Clinical Neurophysiology |
| Volume | 127 |
| Issue number | 2 |
| Pages (from-to) | 1067-72 |
| Number of pages | 6 |
| ISSN | 1388-2457 |
| DOIs | |
| Publication status | Published - 1 Feb 2016 |
Keywords
- Action Potentials
- Adolescent
- Adult
- Aged
- Child
- Epilepsy
- Female
- Humans
- Magnetoencephalography
- Male
- Middle Aged
- Prospective Studies
- Single-Blind Method
- Time Factors
- Young Adult
- Evaluation Studies
- Journal Article
- Research Support, Non-U.S. Gov't