Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography

TY - JOUR

T1 - Visualizing spikes in source-space

T2 - Rapid and efficient evaluation of magnetoencephalography

AU - Beniczky, Sándor

AU - Duez, Lene

AU - Scherg, Michael

AU - Hansen, Peter Orm

AU - Tankisi, Hatice

AU - Sidenius, Per

AU - Sabers, Anne

AU - Pinborg, Lars Hageman

AU - Uldall, Peter

AU - Fuglsang-Frederiksen, Anders

N1 - Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - OBJECTIVE: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space.METHODS: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space.RESULTS: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space.CONCLUSIONS: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space.SIGNIFICANCE: This novel method facilitates the clinical use of MEG.

AB - OBJECTIVE: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space.METHODS: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space.RESULTS: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space.CONCLUSIONS: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space.SIGNIFICANCE: This novel method facilitates the clinical use of MEG.

KW - Action Potentials

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Epilepsy

KW - Female

KW - Humans

KW - Magnetoencephalography

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Single-Blind Method

KW - Time Factors

KW - Young Adult

KW - Evaluation Studies

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.clinph.2015.07.017

DO - 10.1016/j.clinph.2015.07.017

M3 - Journal article

C2 - 26238854

SN - 1388-2457

VL - 127

SP - 1067

EP - 1072

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 2

ER -