Viruses.STRING: A Virus-Host Protein-Protein Interaction Database

Helen Victoria Cook; Nadezhda Tsankova Doncheva; Damian Szklarczyk; Christian von Mering; Lars Juhl Jensen

doi:10.3390/v10100519

Viruses.STRING: A Virus-Host Protein-Protein Interaction Database

Helen Victoria Cook, Nadezhda Tsankova Doncheva, Damian Szklarczyk, Christian von Mering, Lars Juhl Jensen

Disease Systems Biology Program

30 Citations (Scopus)

59 Downloads (Pure)

Abstract

As viruses continue to pose risks to global health, having a better understanding of virus⁻host protein⁻protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein⁻protein interaction database specifically catering to virus⁻virus and virus⁻host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app.

Original language	English
Article number	519
Journal	Viruses
Volume	10
Issue number	10
Pages (from-to)	1-11
ISSN	1999-4915
DOIs	https://doi.org/10.3390/v10100519
Publication status	Published - 2018

Keywords

PPI database
Protein
Protein interactions
Virus bioinformatics
Virus-host interactions
virus bioinformatics
virus-host interactions
protein-protein interactions

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Viruses.STRING: A Virus-Host Protein-Protein Interaction DatabaseFinal published version, 1.06 MB

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title = "Viruses.STRING: A Virus-Host Protein-Protein Interaction Database",

abstract = "As viruses continue to pose risks to global health, having a better understanding of virus⁻host protein⁻protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein⁻protein interaction database specifically catering to virus⁻virus and virus⁻host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app.",

keywords = "PPI database, Protein, Protein interactions, Virus bioinformatics, Virus-host interactions, virus bioinformatics, virus-host interactions, protein-protein interactions",

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T2 - A Virus-Host Protein-Protein Interaction Database

AU - Cook, Helen Victoria

AU - Doncheva, Nadezhda Tsankova

AU - Szklarczyk, Damian

AU - von Mering, Christian

AU - Jensen, Lars Juhl

PY - 2018

Y1 - 2018

N2 - As viruses continue to pose risks to global health, having a better understanding of virus⁻host protein⁻protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein⁻protein interaction database specifically catering to virus⁻virus and virus⁻host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app.

AB - As viruses continue to pose risks to global health, having a better understanding of virus⁻host protein⁻protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein⁻protein interaction database specifically catering to virus⁻virus and virus⁻host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app.

KW - PPI database

KW - Protein

KW - Protein interactions

KW - Virus bioinformatics

KW - Virus-host interactions

KW - virus bioinformatics

KW - virus-host interactions

KW - protein-protein interactions

U2 - 10.3390/v10100519

DO - 10.3390/v10100519

M3 - Journal article

C2 - 30249048

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EP - 11

JO - Viruses

JF - Viruses

IS - 10

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ER -

Viruses.STRING: A Virus-Host Protein-Protein Interaction Database

Abstract

Keywords

UN SDGs

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