Virulence Factors for Hemolytic Uremic Syndrome, Denmark

Steen Ethelberg; Katharina E.P. Olsen; Flemming Scheutz; Charlotte Jensen; Peter Schiellerup; Jørgen Engberg; Andreas Munk Petersen; Bente Olesen; Peter Gerner-Smidt; Kare Mølbak

doi:10.3201/eid1005.030576

Virulence Factors for Hemolytic Uremic Syndrome, Denmark

Steen Ethelberg^*, Katharina E.P. Olsen, Flemming Scheutz, Charlotte Jensen, Peter Schiellerup, Jørgen Engberg, Andreas Munk Petersen, Bente Olesen, Peter Gerner-Smidt, Kare Mølbak

^*Corresponding author for this work

188 Citations (Scopus)

Abstract

We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx₂ genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx₂ (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

Original language	English
Journal	Emerging Infectious Diseases
Volume	10
Issue number	5
Pages (from-to)	842-847
Number of pages	6
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid1005.030576
Publication status	Published - 1 Jan 2004

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title = "Virulence Factors for Hemolytic Uremic Syndrome, Denmark",

abstract = "We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.",

author = "Steen Ethelberg and Olsen, {Katharina E.P.} and Flemming Scheutz and Charlotte Jensen and Peter Schiellerup and J{\o}rgen Engberg and Petersen, {Andreas Munk} and Bente Olesen and Peter Gerner-Smidt and Kare M{\o}lbak",

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T1 - Virulence Factors for Hemolytic Uremic Syndrome, Denmark

AU - Ethelberg, Steen

AU - Olsen, Katharina E.P.

AU - Scheutz, Flemming

AU - Jensen, Charlotte

AU - Schiellerup, Peter

AU - Engberg, Jørgen

AU - Petersen, Andreas Munk

AU - Olesen, Bente

AU - Gerner-Smidt, Peter

AU - Mølbak, Kare

PY - 2004/1/1

Y1 - 2004/1/1

N2 - We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

AB - We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

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DO - 10.3201/eid1005.030576

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AN - SCOPUS:11144354536

SN - 1080-6040

VL - 10

SP - 842

EP - 847

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Virulence Factors for Hemolytic Uremic Syndrome, Denmark

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