Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

Judith M Gottwein; Jens Bukh

doi:10.1038/nrgastro.2013.136

Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

9 Citations (Scopus)

Abstract

With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.

Original language	English
Journal	Nature Reviews. Gastroenterology & Hepatology
Volume	10
Issue number	9
Pages (from-to)	508-9
Number of pages	2
ISSN	1759-5045
DOIs	https://doi.org/10.1038/nrgastro.2013.136
Publication status	Published - 1 Sept 2013

Keywords

Animals
Antibodies, Neutralizing
Female
Hepatitis C
Hepatitis C Antibodies
Humans
Immunization
Viral Hepatitis Vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nrgastro.2013.136

Cite this

@article{e5bf6c9bb6b14d388b72264e9158c30e,

title = "Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen",

abstract = "With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.",

keywords = "Animals, Antibodies, Neutralizing, Female, Hepatitis C, Hepatitis C Antibodies, Humans, Immunization, Viral Hepatitis Vaccines",

author = "Gottwein, {Judith M} and Jens Bukh",

year = "2013",

month = sep,

day = "1",

doi = "10.1038/nrgastro.2013.136",

language = "English",

volume = "10",

pages = "508--9",

journal = "Nature Reviews Gastroenterology and Hepatology",

issn = "1759-5045",

publisher = "nature publishing group",

number = "9",

}

TY - JOUR

T1 - Viral hepatitis

T2 - Cell-culture-derived HCV--a promising vaccine antigen

AU - Gottwein, Judith M

AU - Bukh, Jens

PY - 2013/9/1

Y1 - 2013/9/1

N2 - With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.

AB - With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.

KW - Animals

KW - Antibodies, Neutralizing

KW - Female

KW - Hepatitis C

KW - Hepatitis C Antibodies

KW - Humans

KW - Immunization

KW - Viral Hepatitis Vaccines

U2 - 10.1038/nrgastro.2013.136

DO - 10.1038/nrgastro.2013.136

M3 - Journal article

C2 - 23897287

SN - 1759-5045

VL - 10

SP - 508

EP - 509

JO - Nature Reviews Gastroenterology and Hepatology

JF - Nature Reviews Gastroenterology and Hepatology

IS - 9

ER -

Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this