Venovenøs hæmodiafiltrering til baclofenforgiftet patient

Simon Uhl Nielsen; Tejs Jansen; Sys Stybe Johansen; Kristian Linnet; Peter Gregersen; Lotte Christine Groth Høgberg

Venovenøs hæmodiafiltrering til baclofenforgiftet patient

Translated title of the contribution: Venovenous hemodiafiltration for patient with baclofen intoxication

Simon Uhl Nielsen, Tejs Jansen, Sys Stybe Johansen, Kristian Linnet, Peter Gregersen, Lotte Christine Groth Høgberg

Section of Forensic Chemistry

2 Citations (Scopus)

Abstract

Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.

Translated title of the contribution	Venovenous hemodiafiltration for patient with baclofen intoxication
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	173
Issue number	22
Pages (from-to)	1578-9
Number of pages	2
ISSN	0041-5782
Publication status	Published - May 2011

Cite this

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title = "Venoven{\o}s h{\ae}modiafiltrering til baclofenforgiftet patient",

abstract = "Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.",

keywords = "Baclofen, Drug Overdose, Half-Life, Hemofiltration, Humans, Male, Muscle Relaxants, Central, Suicide, Attempted, Young Adult",

author = "Nielsen, {Simon Uhl} and Tejs Jansen and Johansen, {Sys Stybe} and Kristian Linnet and Peter Gregersen and H{\o}gberg, {Lotte Christine Groth}",

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month = may,

language = "Dansk",

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TY - JOUR

T1 - Venovenøs hæmodiafiltrering til baclofenforgiftet patient

AU - Nielsen, Simon Uhl

AU - Jansen, Tejs

AU - Johansen, Sys Stybe

AU - Linnet, Kristian

AU - Gregersen, Peter

AU - Høgberg, Lotte Christine Groth

PY - 2011/5

Y1 - 2011/5

N2 - Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.

AB - Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.

KW - Baclofen

KW - Drug Overdose

KW - Half-Life

KW - Hemofiltration

KW - Humans

KW - Male

KW - Muscle Relaxants, Central

KW - Suicide, Attempted

KW - Young Adult

M3 - Tidsskriftartikel

C2 - 21627904

SN - 0041-5782

VL - 173

SP - 1578

EP - 1579

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 22

ER -

Venovenøs hæmodiafiltrering til baclofenforgiftet patient

Abstract

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