Venovenøs hæmodiafiltrering til baclofenforgiftet patient

Simon Uhl Nielsen; Tejs Jansen; Sys Stybe Johansen; Kristian Linnet; Peter Gregersen; Lotte Christine Groth Høgberg

Venovenøs hæmodiafiltrering til baclofenforgiftet patient

Simon Uhl Nielsen, Tejs Jansen, Sys Stybe Johansen, Kristian Linnet, Peter Gregersen, Lotte Christine Groth Høgberg

Afdeling for Retskemi

2 Citationer (Scopus)

Abstract

Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.

Bidragets oversatte titel	Venovenous hemodiafiltration for patient with baclofen intoxication
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	173
Udgave nummer	22
Sider (fra-til)	1578-9
Antal sider	2
ISSN	0041-5782
Status	Udgivet - maj 2011

Emneord

Baclofen
Drug Overdose
Half-Life
Hemofiltration
Humans
Male
Muscle Relaxants, Central
Suicide, Attempted
Young Adult

Citationsformater

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keywords = "Baclofen, Drug Overdose, Half-Life, Hemofiltration, Humans, Male, Muscle Relaxants, Central, Suicide, Attempted, Young Adult",

author = "Nielsen, {Simon Uhl} and Tejs Jansen and Johansen, {Sys Stybe} and Kristian Linnet and Peter Gregersen and H{\o}gberg, {Lotte Christine Groth}",

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language = "Dansk",

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T1 - Venovenøs hæmodiafiltrering til baclofenforgiftet patient

AU - Nielsen, Simon Uhl

AU - Jansen, Tejs

AU - Johansen, Sys Stybe

AU - Linnet, Kristian

AU - Gregersen, Peter

AU - Høgberg, Lotte Christine Groth

PY - 2011/5

Y1 - 2011/5

N2 - Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.

AB - Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.

KW - Baclofen

KW - Drug Overdose

KW - Half-Life

KW - Hemofiltration

KW - Humans

KW - Male

KW - Muscle Relaxants, Central

KW - Suicide, Attempted

KW - Young Adult

M3 - Tidsskriftartikel

C2 - 21627904

SN - 0041-5782

VL - 173

SP - 1578

EP - 1579

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 22

ER -

Venovenøs hæmodiafiltrering til baclofenforgiftet patient

Abstract

Emneord

Fingeraftryk

Citationsformater