Vena porta thrombosis in patient with inherited factor VII deficiency

Jolanta Klovaite; Lennart Jan Friis-Hansen; Fin S Larsen; Nielsaage Toffner-Clausen; Ole W Bjerrum

doi:10.1097/mbc.0b013e3283370166

Vena porta thrombosis in patient with inherited factor VII deficiency

Jolanta Klovaite, Lennart Jan Friis-Hansen, Fin S Larsen, Nielsaage Toffner-Clausen, Ole W Bjerrum

Department of Clinical Medicine

3 Citations (Scopus)

Abstract

Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.

Original language	English
Journal	Blood Coagulation and Fibrinolysis
Volume	21
Issue number	3
Pages (from-to)	285-8
Number of pages	4
ISSN	0957-5235
DOIs	https://doi.org/10.1097/mbc.0b013e3283370166
Publication status	Published - 1 Apr 2010

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title = "Vena porta thrombosis in patient with inherited factor VII deficiency",

abstract = "Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.",

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T1 - Vena porta thrombosis in patient with inherited factor VII deficiency

AU - Klovaite, Jolanta

AU - Friis-Hansen, Lennart Jan

AU - Larsen, Fin S

AU - Toffner-Clausen, Nielsaage

AU - Bjerrum, Ole W

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.

AB - Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.

U2 - 10.1097/mbc.0b013e3283370166

DO - 10.1097/mbc.0b013e3283370166

M3 - Journal article

SN - 0957-5235

VL - 21

SP - 285

EP - 288

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

IS - 3

ER -

Vena porta thrombosis in patient with inherited factor VII deficiency

Abstract

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