Vena porta thrombosis in patient with inherited factor VII deficiency

Jolanta Klovaite; Lennart Jan Friis-Hansen; Fin S Larsen; Nielsaage Toffner-Clausen; Ole W Bjerrum

doi:10.1097/mbc.0b013e3283370166

Vena porta thrombosis in patient with inherited factor VII deficiency

Jolanta Klovaite, Lennart Jan Friis-Hansen, Fin S Larsen, Nielsaage Toffner-Clausen, Ole W Bjerrum

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.

Originalsprog	Engelsk
Tidsskrift	Blood Coagulation and Fibrinolysis
Vol/bind	21
Udgave nummer	3
Sider (fra-til)	285-8
Antal sider	4
ISSN	0957-5235
DOI	https://doi.org/10.1097/mbc.0b013e3283370166
Status	Udgivet - 1 apr. 2010

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10.1097/mbc.0b013e3283370166

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title = "Vena porta thrombosis in patient with inherited factor VII deficiency",

abstract = "Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.",

author = "Jolanta Klovaite and Friis-Hansen, {Lennart Jan} and Larsen, {Fin S} and Nielsaage Toffner-Clausen and Bjerrum, {Ole W}",

year = "2010",

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doi = "10.1097/mbc.0b013e3283370166",

language = "English",

volume = "21",

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TY - JOUR

T1 - Vena porta thrombosis in patient with inherited factor VII deficiency

AU - Klovaite, Jolanta

AU - Friis-Hansen, Lennart Jan

AU - Larsen, Fin S

AU - Toffner-Clausen, Nielsaage

AU - Bjerrum, Ole W

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.

AB - Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.

U2 - 10.1097/mbc.0b013e3283370166

DO - 10.1097/mbc.0b013e3283370166

M3 - Journal article

SN - 0957-5235

VL - 21

SP - 285

EP - 288

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

IS - 3

ER -

Vena porta thrombosis in patient with inherited factor VII deficiency

Abstract

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