Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Y H Hamid; C S Rose; S A Urhammer; C Glümer; R Nolsøe; O P Kristiansen; Thomas Mandrup-Poulsen; K Borch-Johnsen; T Jorgensen; T Hansen; O Pedersen

doi:10.1007/s00125-004-1623-0

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Y H Hamid, C S Rose, S A Urhammer, C Glümer, R Nolsøe, O P Kristiansen, Thomas Mandrup-Poulsen, K Borch-Johnsen, T Jorgensen, T Hansen, O Pedersen

125 Citations (Scopus)

Abstract

The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.

Original language	English
Journal	Diabetologia
Volume	48
Issue number	2
Pages (from-to)	251-60
Number of pages	10
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-004-1623-0
Publication status	Published - 1 Feb 2005

Keywords

Base Sequence
Cohort Studies
DNA Primers
Denmark
European Continental Ancestry Group
Female
Gene Frequency
Genetic Variation
Genotype
Humans
Interleukin-6
Male
Metabolic Syndrome X
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Promoter Regions, Genetic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-004-1623-0

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abstract = "The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.",

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T1 - Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

AU - Hamid, Y H

AU - Rose, C S

AU - Urhammer, S A

AU - Glümer, C

AU - Nolsøe, R

AU - Kristiansen, O P

AU - Mandrup-Poulsen, Thomas

AU - Borch-Johnsen, K

AU - Jorgensen, T

AU - Hansen, T

AU - Pedersen, O

PY - 2005/2/1

Y1 - 2005/2/1

N2 - The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.

AB - The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.

KW - Base Sequence

KW - Cohort Studies

KW - DNA Primers

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Interleukin-6

KW - Male

KW - Metabolic Syndrome X

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

U2 - 10.1007/s00125-004-1623-0

DO - 10.1007/s00125-004-1623-0

M3 - Journal article

C2 - 15645209

SN - 0012-186X

VL - 48

SP - 251

EP - 260

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Abstract

Keywords

UN SDGs

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