Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Y H Hamid; C S Rose; S A Urhammer; C Glümer; R Nolsøe; O P Kristiansen; Thomas Mandrup-Poulsen; K Borch-Johnsen; T Jorgensen; T Hansen; O Pedersen

doi:10.1007/s00125-004-1623-0

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Y H Hamid, C S Rose, S A Urhammer, C Glümer, R Nolsøe, O P Kristiansen, Thomas Mandrup-Poulsen, K Borch-Johnsen, T Jorgensen, T Hansen, O Pedersen

125 Citationer (Scopus)

Abstract

The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	48
Udgave nummer	2
Sider (fra-til)	251-60
Antal sider	10
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-004-1623-0
Status	Udgivet - 1 feb. 2005

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1007/s00125-004-1623-0

Citationsformater

@article{1cd6fbd4d5334fe184dab4cf56c67b2b,

title = "Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes",

abstract = "The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.",

keywords = "Base Sequence, Cohort Studies, DNA Primers, Denmark, European Continental Ancestry Group, Female, Gene Frequency, Genetic Variation, Genotype, Humans, Interleukin-6, Male, Metabolic Syndrome X, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Promoter Regions, Genetic",

author = "Hamid, {Y H} and Rose, {C S} and Urhammer, {S A} and C Gl{\"u}mer and R Nols{\o}e and Kristiansen, {O P} and Thomas Mandrup-Poulsen and K Borch-Johnsen and T Jorgensen and T Hansen and O Pedersen",

year = "2005",

month = feb,

day = "1",

doi = "10.1007/s00125-004-1623-0",

language = "English",

volume = "48",

pages = "251--60",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

AU - Hamid, Y H

AU - Rose, C S

AU - Urhammer, S A

AU - Glümer, C

AU - Nolsøe, R

AU - Kristiansen, O P

AU - Mandrup-Poulsen, Thomas

AU - Borch-Johnsen, K

AU - Jorgensen, T

AU - Hansen, T

AU - Pedersen, O

PY - 2005/2/1

Y1 - 2005/2/1

N2 - The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.

AB - The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.

KW - Base Sequence

KW - Cohort Studies

KW - DNA Primers

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Interleukin-6

KW - Male

KW - Metabolic Syndrome X

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

U2 - 10.1007/s00125-004-1623-0

DO - 10.1007/s00125-004-1623-0

M3 - Journal article

C2 - 15645209

SN - 0012-186X

VL - 48

SP - 251

EP - 260

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater