Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas Hansen; Klaus D Jakobsen; Mogens Fenger; Jimmi Nielsen; Karoline Krane; Anders Fink-Jensen; Henrik Lublin; Henrik Ullum; Sally Timm; August G Wang; Niklas Rye Jørgensen; Thomas Werge

doi:10.1016/j.schres.2008.05.026

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas Hansen, Klaus D Jakobsen, Mogens Fenger, Jimmi Nielsen, Karoline Krane, Anders Fink-Jensen, Henrik Lublin, Henrik Ullum, Sally Timm, August G Wang, Niklas Rye Jørgensen, Thomas Werge

20 Citations (Scopus)

Abstract

The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia.

Original language	English
Journal	Schizophrenia Research
Volume	104
Issue number	1-3
Pages (from-to)	146-52
Number of pages	7
ISSN	0920-9964
DOIs	https://doi.org/10.1016/j.schres.2008.05.026
Publication status	Published - 2008

Keywords

Adult
Aged
Aged, 80 and over
Alleles
Denmark
European Continental Ancestry Group
Female
Genetic Variation
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Purinergic P2
Receptors, Purinergic P2X7
Schizophrenia
Young Adult

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10.1016/j.schres.2008.05.026

Cite this

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title = "Variation in the purinergic P2RX(7) receptor gene and schizophrenia",

abstract = "The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia.",

keywords = "Adult, Aged, Aged, 80 and over, Alleles, Denmark, European Continental Ancestry Group, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Purinergic P2, Receptors, Purinergic P2X7, Schizophrenia, Young Adult",

author = "Thomas Hansen and Jakobsen, {Klaus D} and Mogens Fenger and Jimmi Nielsen and Karoline Krane and Anders Fink-Jensen and Henrik Lublin and Henrik Ullum and Sally Timm and Wang, {August G} and J{\o}rgensen, {Niklas Rye} and Thomas Werge",

note = "Keywords: Adult; Aged; Aged, 80 and over; Alleles; Denmark; European Continental Ancestry Group; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Schizophrenia; Young Adult",

year = "2008",

doi = "10.1016/j.schres.2008.05.026",

language = "English",

volume = "104",

pages = "146--52",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

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T1 - Variation in the purinergic P2RX(7) receptor gene and schizophrenia

AU - Hansen, Thomas

AU - Jakobsen, Klaus D

AU - Fenger, Mogens

AU - Nielsen, Jimmi

AU - Krane, Karoline

AU - Fink-Jensen, Anders

AU - Lublin, Henrik

AU - Ullum, Henrik

AU - Timm, Sally

AU - Wang, August G

AU - Jørgensen, Niklas Rye

AU - Werge, Thomas

N1 - Keywords: Adult; Aged; Aged, 80 and over; Alleles; Denmark; European Continental Ancestry Group; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Schizophrenia; Young Adult

PY - 2008

Y1 - 2008

N2 - The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia.

AB - The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alleles

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Receptors, Purinergic P2

KW - Receptors, Purinergic P2X7

KW - Schizophrenia

KW - Young Adult

U2 - 10.1016/j.schres.2008.05.026

DO - 10.1016/j.schres.2008.05.026

M3 - Journal article

C2 - 18614336

SN - 0920-9964

VL - 104

SP - 146

EP - 152

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Abstract

Keywords

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